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Interactions of MinK and e-NOS Gene Polymorphisms Appear to Be Inconsistent Predictors of Atrial Fibrillation Propensity, but Long Alleles of ESR1 Promoter TA Repeat May Be a Promising Marker

Anton Šmalcelj ; Department of Cardiovascular Diseases, University Hospital Centre »Zagreb«, School of Medicine, University of Zagreb, Zagreb, Croatia
Jadranka Sertić ; Department of Laboratory Diagnostics, University Hospital Centre »Zagreb«, School of Medicine, University of Zagreb, Zagreb, Croatia
Karlo Golubić ; Department of Cardiovascular Diseases, University Hospital Centre »Zagreb«, School of Medicine, University of Zagreb, Zagreb, Croatia
Ljiljana Jurčić ; Department of Laboratory Diagnostics, University Hospital Centre »Zagreb«, School of Medicine, University of Zagreb, Zagreb, Croatia
Ljiljana Banfić ; Department of Cardiovascular Diseases, University Hospital Centre »Zagreb«, School of Medicine, University of Zagreb, Zagreb, Croatia
Margarita Brida ; Department of Cardiovascular Diseases, University Hospital Centre »Zagreb«, School of Medicine, University of Zagreb, Zagreb, Croatia

Puni tekst: engleski, pdf (68 KB) str. 933-937 preuzimanja: 261* citiraj
APA 6th Edition
Šmalcelj, A., Sertić, J., Golubić, K., Jurčić, Lj., Banfić, Lj. i Brida, M. (2009). Interactions of MinK and e-NOS Gene Polymorphisms Appear to Be Inconsistent Predictors of Atrial Fibrillation Propensity, but Long Alleles of ESR1 Promoter TA Repeat May Be a Promising Marker. Collegium antropologicum, 33 (3), 933-937. Preuzeto s https://hrcak.srce.hr/41854
MLA 8th Edition
Šmalcelj, Anton, et al. "Interactions of MinK and e-NOS Gene Polymorphisms Appear to Be Inconsistent Predictors of Atrial Fibrillation Propensity, but Long Alleles of ESR1 Promoter TA Repeat May Be a Promising Marker." Collegium antropologicum, vol. 33, br. 3, 2009, str. 933-937. https://hrcak.srce.hr/41854. Citirano 22.07.2019.
Chicago 17th Edition
Šmalcelj, Anton, Jadranka Sertić, Karlo Golubić, Ljiljana Jurčić, Ljiljana Banfić i Margarita Brida. "Interactions of MinK and e-NOS Gene Polymorphisms Appear to Be Inconsistent Predictors of Atrial Fibrillation Propensity, but Long Alleles of ESR1 Promoter TA Repeat May Be a Promising Marker." Collegium antropologicum 33, br. 3 (2009): 933-937. https://hrcak.srce.hr/41854
Harvard
Šmalcelj, A., et al. (2009). 'Interactions of MinK and e-NOS Gene Polymorphisms Appear to Be Inconsistent Predictors of Atrial Fibrillation Propensity, but Long Alleles of ESR1 Promoter TA Repeat May Be a Promising Marker', Collegium antropologicum, 33(3), str. 933-937. Preuzeto s: https://hrcak.srce.hr/41854 (Datum pristupa: 22.07.2019.)
Vancouver
Šmalcelj A, Sertić J, Golubić K, Jurčić Lj, Banfić Lj, Brida M. Interactions of MinK and e-NOS Gene Polymorphisms Appear to Be Inconsistent Predictors of Atrial Fibrillation Propensity, but Long Alleles of ESR1 Promoter TA Repeat May Be a Promising Marker. Collegium antropologicum [Internet]. 2009 [pristupljeno 22.07.2019.];33(3):933-937. Dostupno na: https://hrcak.srce.hr/41854
IEEE
A. Šmalcelj, J. Sertić, K. Golubić, Lj. Jurčić, Lj. Banfić i M. Brida, "Interactions of MinK and e-NOS Gene Polymorphisms Appear to Be Inconsistent Predictors of Atrial Fibrillation Propensity, but Long Alleles of ESR1 Promoter TA Repeat May Be a Promising Marker", Collegium antropologicum, vol.33, br. 3, str. 933-937, 2009. [Online]. Dostupno na: https://hrcak.srce.hr/41854. [Citirano: 22.07.2019.]

Sažetak
Interactions of MinK and e-NOS Gene Polymorphisms Appear to Be Inconsistent Predictors of Atrial Fibrillation Propensity, but Long Alleles of ESR1 Promoter TA Repeat May Be a Promising Marker. We analyzed minK, e-NOS and ESR1 gene polymorphisms in 40 patients with atrial fibrillation (AF) without major structural heart disease compared to 35 healthy controls. A missense polymorphism in the minK gene with A/G substitution at nucleotide 112 causing serine (S) to glycine (G) change, 786 T/C polymorphism in the 5’ flanking region of e-NOS gene and TA polymorphism in the regulatory region of estrogen receptor ESR1 gene with long (ł19 TA repeats) and short alleles were examined. Only a slight increase in minK G allele frequency, but with marked excess in AG/TT combination of minK and e-NOS polymorphisms was found in the AF group. The interpretation remains tentative due to small groups precluding statistical significance of differences, possible lab flaws and inconsistencies with earlier data. However, ESR1 long allele homozygotes were strikingly more frequent in the AF than in control group, reaching statistical significance surprisingly in males (p<0.02). Functional activity of estrogen receptors may be more critical in males than in females with abundance of circulating estrogen. Contrasting the intricate complexity of genetic polymorphisms influencing cardiac rhythm with our modest research, we would limit the conclusion to the plea for further research of ESR1 role in AF.

Ključne riječi
atrial fibrillation; gene polymorphisms; minK gene; e-NOS gene; ESR1gene

Hrčak ID: 41854

URI
https://hrcak.srce.hr/41854

Posjeta: 461 *