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Association of Polymorphism of the MBL2 Gene in Type 2 Diabetic Patients with Periodontitis: A Preliminary Study

Natalia COSTA ARAUJO ; Federal University of Pernambuco, Recife, Pernambuco, Brazil
Darcyla Maria de AGUIAR BELLO ; Federal University of Pernambuco, Recife, Pernambuco, Brazil
Paulo Roberto Eleutério de SOUZA ; Department of Biology, Rural Federal University of Pernambuco, Recife, Pernambuco, Brazil
Renata Cimões   ORCID icon orcid.org/0000-0003-3673-8739 ; Department of Prosthesis and Oral and Facial Surgery, School of Dentistry Federal University of Pernambuco, Recife, Pernambuco, Brazil

Puni tekst: engleski, pdf (409 KB) str. 290-300 preuzimanja: 266* citiraj
APA 6th Edition
COSTA ARAUJO, N., AGUIAR BELLO, D.M.d., SOUZA, P.R.E.d. i Cimões, R. (2009). Association of Polymorphism of the MBL2 Gene in Type 2 Diabetic Patients with Periodontitis: A Preliminary Study. Acta stomatologica Croatica, 43 (4), 290-300. Preuzeto s https://hrcak.srce.hr/45302
MLA 8th Edition
COSTA ARAUJO, Natalia, et al. "Association of Polymorphism of the MBL2 Gene in Type 2 Diabetic Patients with Periodontitis: A Preliminary Study." Acta stomatologica Croatica, vol. 43, br. 4, 2009, str. 290-300. https://hrcak.srce.hr/45302. Citirano 10.05.2021.
Chicago 17th Edition
COSTA ARAUJO, Natalia, Darcyla Maria de AGUIAR BELLO, Paulo Roberto Eleutério de SOUZA i Renata Cimões. "Association of Polymorphism of the MBL2 Gene in Type 2 Diabetic Patients with Periodontitis: A Preliminary Study." Acta stomatologica Croatica 43, br. 4 (2009): 290-300. https://hrcak.srce.hr/45302
Harvard
COSTA ARAUJO, N., et al. (2009). 'Association of Polymorphism of the MBL2 Gene in Type 2 Diabetic Patients with Periodontitis: A Preliminary Study', Acta stomatologica Croatica, 43(4), str. 290-300. Preuzeto s: https://hrcak.srce.hr/45302 (Datum pristupa: 10.05.2021.)
Vancouver
COSTA ARAUJO N, AGUIAR BELLO DMd, SOUZA PREd, Cimões R. Association of Polymorphism of the MBL2 Gene in Type 2 Diabetic Patients with Periodontitis: A Preliminary Study. Acta stomatologica Croatica [Internet]. 2009 [pristupljeno 10.05.2021.];43(4):290-300. Dostupno na: https://hrcak.srce.hr/45302
IEEE
N. COSTA ARAUJO, D.M.d. AGUIAR BELLO, P.R.E.d. SOUZA i R. Cimões, "Association of Polymorphism of the MBL2 Gene in Type 2 Diabetic Patients with Periodontitis: A Preliminary Study", Acta stomatologica Croatica, vol.43, br. 4, str. 290-300, 2009. [Online]. Dostupno na: https://hrcak.srce.hr/45302. [Citirano: 10.05.2021.]
Puni tekst: hrvatski, pdf (409 KB) str. 290-300 preuzimanja: 460* citiraj
APA 6th Edition
COSTA ARAUJO, N., AGUIAR BELLO, D.M.d., SOUZA, P.R.E.d. i Cimões, R. (2009). Povezanost polimorfizma gena MBL-2 s parodontitisom kod pacijenata s dijabetesom tipa 2: preliminarno istraživanje. Acta stomatologica Croatica, 43 (4), 290-300. Preuzeto s https://hrcak.srce.hr/45302
MLA 8th Edition
COSTA ARAUJO, Natalia, et al. "Povezanost polimorfizma gena MBL-2 s parodontitisom kod pacijenata s dijabetesom tipa 2: preliminarno istraživanje." Acta stomatologica Croatica, vol. 43, br. 4, 2009, str. 290-300. https://hrcak.srce.hr/45302. Citirano 10.05.2021.
Chicago 17th Edition
COSTA ARAUJO, Natalia, Darcyla Maria de AGUIAR BELLO, Paulo Roberto Eleutério de SOUZA i Renata Cimões. "Povezanost polimorfizma gena MBL-2 s parodontitisom kod pacijenata s dijabetesom tipa 2: preliminarno istraživanje." Acta stomatologica Croatica 43, br. 4 (2009): 290-300. https://hrcak.srce.hr/45302
Harvard
COSTA ARAUJO, N., et al. (2009). 'Povezanost polimorfizma gena MBL-2 s parodontitisom kod pacijenata s dijabetesom tipa 2: preliminarno istraživanje', Acta stomatologica Croatica, 43(4), str. 290-300. Preuzeto s: https://hrcak.srce.hr/45302 (Datum pristupa: 10.05.2021.)
Vancouver
COSTA ARAUJO N, AGUIAR BELLO DMd, SOUZA PREd, Cimões R. Povezanost polimorfizma gena MBL-2 s parodontitisom kod pacijenata s dijabetesom tipa 2: preliminarno istraživanje. Acta stomatologica Croatica [Internet]. 2009 [pristupljeno 10.05.2021.];43(4):290-300. Dostupno na: https://hrcak.srce.hr/45302
IEEE
N. COSTA ARAUJO, D.M.d. AGUIAR BELLO, P.R.E.d. SOUZA i R. Cimões, "Povezanost polimorfizma gena MBL-2 s parodontitisom kod pacijenata s dijabetesom tipa 2: preliminarno istraživanje", Acta stomatologica Croatica, vol.43, br. 4, str. 290-300, 2009. [Online]. Dostupno na: https://hrcak.srce.hr/45302. [Citirano: 10.05.2021.]

Sažetak
Aim: Mannose-binding lectin (MBL) is an important protein of the innate immune system. It is able to bind to sugar groups encountered on the surfaces of a wide range of microorganisms and interacts with serine proteases (MASPs) to effect the activation of complement. Mutations of the expressed human MBL2 gene have been associated with several infections; this preliminary study thus sets out to assess the association between the polymorphism in exon-1 of the MBL2 gene and periodontal disease in type 2 diabetic patients. Material and Methods: The sample comprised 50 diabetic patients, who were submitted to a clinical periodontal examination that evaluated in six sites per tooth probing depth, bleeding on probing, clinical recession, dental plaque and the number of teeth present. Periodontal disease was defined as 4+ sites of loss of attachment of 5+ mm, with one or more of those sites having a pocket of 4+ mm (Beck’s criteria). The collection of scaling cells from the oral mucosa was carried out and the detection of polymorphism was made by the technique of real time PCR (RT-PCR) using the melting temperature curve analysis. Results: The data revealed that no statistically significant differences in the genotype (p=0.564) or the allele (p=0.643) frequencies were observed among the healthy individuals or those with periodontitis. Conclusions: The polymorphism in exon-1 of the MBL2 gene was not related to the periodontal disease in the sample evaluated.

Ključne riječi
Mannose-Binding Lectin; Polymorphism, Genetic; Periodontitis; Diabetes Mellitus, Type 2

Hrčak ID: 45302

URI
https://hrcak.srce.hr/45302

[hrvatski]

Posjeta: 1.072 *