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https://doi.org/10.2478/10004-1254-60-2009-1971

Inflammatory and Haematotoxic Potential of Indoor Stachybotrys chartarum (Ehrenb.) Hughes Metabolites

Elena Piecková ; Slovak Medical University, Bratislava, Slovakia
Marta Hurbánková ; Slovak Medical University, Bratislava, Slovakia
Silvia Černá ; Slovak Medical University, Bratislava, Slovakia
Aurélia Lišková ; Slovak Medical University, Bratislava, Slovakia
Zuzana Kováčiková ; Slovak Medical University, Bratislava, Slovakia
Zuzana Kolláriková ; Slovak Medical University, Bratislava, Slovakia
Soňa Wimmerová ; Slovak Medical University, Bratislava, Slovakia

Puni tekst: engleski, pdf (157 KB) str. 401-408 preuzimanja: 454* citiraj
APA 6th Edition
Piecková, E., Hurbánková, M., Černá, S., Lišková, A., Kováčiková, Z., Kolláriková, Z. i Wimmerová, S. (2009). Inflammatory and Haematotoxic Potential of Indoor Stachybotrys chartarum (Ehrenb.) Hughes Metabolites. Arhiv za higijenu rada i toksikologiju, 60 (4), 401-408. https://doi.org/10.2478/10004-1254-60-2009-1971
MLA 8th Edition
Piecková, Elena, et al. "Inflammatory and Haematotoxic Potential of Indoor Stachybotrys chartarum (Ehrenb.) Hughes Metabolites." Arhiv za higijenu rada i toksikologiju, vol. 60, br. 4, 2009, str. 401-408. https://doi.org/10.2478/10004-1254-60-2009-1971. Citirano 06.03.2021.
Chicago 17th Edition
Piecková, Elena, Marta Hurbánková, Silvia Černá, Aurélia Lišková, Zuzana Kováčiková, Zuzana Kolláriková i Soňa Wimmerová. "Inflammatory and Haematotoxic Potential of Indoor Stachybotrys chartarum (Ehrenb.) Hughes Metabolites." Arhiv za higijenu rada i toksikologiju 60, br. 4 (2009): 401-408. https://doi.org/10.2478/10004-1254-60-2009-1971
Harvard
Piecková, E., et al. (2009). 'Inflammatory and Haematotoxic Potential of Indoor Stachybotrys chartarum (Ehrenb.) Hughes Metabolites', Arhiv za higijenu rada i toksikologiju, 60(4), str. 401-408. https://doi.org/10.2478/10004-1254-60-2009-1971
Vancouver
Piecková E, Hurbánková M, Černá S, Lišková A, Kováčiková Z, Kolláriková Z i sur. Inflammatory and Haematotoxic Potential of Indoor Stachybotrys chartarum (Ehrenb.) Hughes Metabolites. Arh Hig Rada Toksikol. [Internet]. 2009 [pristupljeno 06.03.2021.];60(4):401-408. https://doi.org/10.2478/10004-1254-60-2009-1971
IEEE
E. Piecková, et al., "Inflammatory and Haematotoxic Potential of Indoor Stachybotrys chartarum (Ehrenb.) Hughes Metabolites", Arhiv za higijenu rada i toksikologiju, vol.60, br. 4, str. 401-408, 2009. [Online]. https://doi.org/10.2478/10004-1254-60-2009-1971

Sažetak
Mould Stachybotrys chartarum (Ehrenb.) Hughes is known to pose a health risk in indoor environments. Most of its strains can produce several intra- and extracellular trichothecene mycotoxins. Complex secondary metabolites of stachybotrys isolates from mouldy dwellings/public buildings in Slovakia were intratracheally instilled in Wistar male rats (4 μg in 0.2 mL of 0.2 % dimethylsulphoxide; diacetoxyscirpenol as the positive control). After three days, haematological parameters were measured in peripheral blood
and infl ammatory response biomarkers in bronchoalveolar lavage fl uid (BALF), and the results were statistically analysed. Exometabolites proved to suppress red blood cell (RBC), decreasing the total RBC count, haemoglobin, and haematocrit. The exposed rats showed signifi cantly higher total BALF cell count, indicating infl ammation, lower alveolar macrophage counts, and increased granulocyte count related to the BALF cells. Due to haematotoxic and infl ammation-inducing properties, metabolites of S. chartarum can
cause damage to the airways and haematological disorders in occupants of mouldy buildings.

Ključne riječi
infl ammation; intratracheal instillation; moulds; rats; red blood cells

Hrčak ID: 45372

URI
https://hrcak.srce.hr/45372

[hrvatski]

Posjeta: 946 *