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Arhiv za higijenu rada i toksikologiju, Vol. 60 No. 4, 2009.

Pregledni rad
https://doi.org/10.2478/10004-1254-60-2009-2000

Ochratoxin A and Aristolochic Acid Involvement in Nephropathies and Associated Urothelial Tract Tumours

Annie Pfohl-Leszkowicz ; University of Toulouse, Lab Chemical Engineering, Department Bioprocess & Microbial System, Auzeville-Tolosane, France

Puni tekst: engleski, pdf (369 KB) str. 465-482 preuzimanja: 740* citiraj
APA 6th Edition
Pfohl-Leszkowicz, A. (2009). Ochratoxin A and Aristolochic Acid Involvement in Nephropathies and Associated Urothelial Tract Tumours. Arhiv za higijenu rada i toksikologiju, 60 (4), 465-482. https://doi.org/10.2478/10004-1254-60-2009-2000
MLA 8th Edition
Pfohl-Leszkowicz, Annie. "Ochratoxin A and Aristolochic Acid Involvement in Nephropathies and Associated Urothelial Tract Tumours." Arhiv za higijenu rada i toksikologiju, vol. 60, br. 4, 2009, str. 465-482. https://doi.org/10.2478/10004-1254-60-2009-2000. Citirano 07.03.2021.
Chicago 17th Edition
Pfohl-Leszkowicz, Annie. "Ochratoxin A and Aristolochic Acid Involvement in Nephropathies and Associated Urothelial Tract Tumours." Arhiv za higijenu rada i toksikologiju 60, br. 4 (2009): 465-482. https://doi.org/10.2478/10004-1254-60-2009-2000
Harvard
Pfohl-Leszkowicz, A. (2009). 'Ochratoxin A and Aristolochic Acid Involvement in Nephropathies and Associated Urothelial Tract Tumours', Arhiv za higijenu rada i toksikologiju, 60(4), str. 465-482. https://doi.org/10.2478/10004-1254-60-2009-2000
Vancouver
Pfohl-Leszkowicz A. Ochratoxin A and Aristolochic Acid Involvement in Nephropathies and Associated Urothelial Tract Tumours. Arh Hig Rada Toksikol. [Internet]. 2009 [pristupljeno 07.03.2021.];60(4):465-482. https://doi.org/10.2478/10004-1254-60-2009-2000
IEEE
A. Pfohl-Leszkowicz, "Ochratoxin A and Aristolochic Acid Involvement in Nephropathies and Associated Urothelial Tract Tumours", Arhiv za higijenu rada i toksikologiju, vol.60, br. 4, str. 465-482, 2009. [Online]. https://doi.org/10.2478/10004-1254-60-2009-2000

Sažetak
This review addresses the unresolved aetiology of several nephropathies and associated upper tract tumours diagnosed all over the world, but especially in the Balkan regions. Studies conducted over the last 35 years point to mycotoxins, mainly ochratoxin A (OTA) as the main culprit. Recent theories however have implicated aristolochic acids (AA). The aim of this review is to put forward arguments in favour of the mycotoxin theory and to show the incoherence of the AA theory. It discusses the differences between the epidemiology of Balkan endemic nephropathy (BEN) and aristolochic acid nephropathy (AAN); OTA and AA carcinogenicity; clinical and pathological effects induced by OTA and AA; sources of OTA contamination (food, air, drinking water); OTA- and AA-DNA adduct formation; the role of genetic polymorphisms ; and the risk for young children.

Ključne riječi
aetiology; contamination; DNA adduct; genetic polymorphism; pathological effects; urothelial cancer

Hrčak ID: 45394

URI
https://hrcak.srce.hr/45394

[hrvatski]

Posjeta: 1.257 *