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Demonstrating Reduced Environmental and Genetic Diversity in Human Isolates by Analysis of Blood Lipid Levels

Ozren Polašek
Ivana Kolčić
Ankica Smoljanović
Dražen Stojanović
Matijana Grgić
Barbara Ebling
Maja Klarić
Josip Milas
Dinko Puntarić

Puni tekst: engleski, pdf (667 KB) str. 649-655 preuzimanja: 238* citiraj
APA 6th Edition
Polašek, O., Kolčić, I., Smoljanović, A., Stojanović, D., Grgić, M., Ebling, B., ... Puntarić, D. (2006). Demonstrating Reduced Environmental and Genetic Diversity in Human Isolates by Analysis of Blood Lipid Levels. Croatian medical journal, 47 (4), 649-655. Preuzeto s https://hrcak.srce.hr/4386
MLA 8th Edition
Polašek, Ozren, et al. "Demonstrating Reduced Environmental and Genetic Diversity in Human Isolates by Analysis of Blood Lipid Levels." Croatian medical journal, vol. 47, br. 4, 2006, str. 649-655. https://hrcak.srce.hr/4386. Citirano 22.11.2019.
Chicago 17th Edition
Polašek, Ozren, Ivana Kolčić, Ankica Smoljanović, Dražen Stojanović, Matijana Grgić, Barbara Ebling, Maja Klarić, Josip Milas i Dinko Puntarić. "Demonstrating Reduced Environmental and Genetic Diversity in Human Isolates by Analysis of Blood Lipid Levels." Croatian medical journal 47, br. 4 (2006): 649-655. https://hrcak.srce.hr/4386
Harvard
Polašek, O., et al. (2006). 'Demonstrating Reduced Environmental and Genetic Diversity in Human Isolates by Analysis of Blood Lipid Levels', Croatian medical journal, 47(4), str. 649-655. Preuzeto s: https://hrcak.srce.hr/4386 (Datum pristupa: 22.11.2019.)
Vancouver
Polašek O, Kolčić I, Smoljanović A, Stojanović D, Grgić M, Ebling B i sur. Demonstrating Reduced Environmental and Genetic Diversity in Human Isolates by Analysis of Blood Lipid Levels. Croat Med J. [Internet]. 2006 [pristupljeno 22.11.2019.];47(4):649-655. Dostupno na: https://hrcak.srce.hr/4386
IEEE
O. Polašek, et al., "Demonstrating Reduced Environmental and Genetic Diversity in Human Isolates by Analysis of Blood Lipid Levels", Croatian medical journal, vol.47, br. 4, str. 649-655, 2006. [Online]. Dostupno na: https://hrcak.srce.hr/4386. [Citirano: 22.11.2019.]

Sažetak
Aim: To test the hypothesis that phenotypic diversity in isolated human populations is decreased in comparison with general outbred population because of reduced genetic and environmental diversity. To demonstrate this in populations for which reduced genetic and environmental diversity had already been established, by studying the amount of variation in plasma lipid levels.
Methods: Fasting plasma lipid levels (cholesterol, triglycerides, low density lipoprotein [LDL], and high density lipoprotein [HDL]) were measured in randomly selected 300 inhabitants from 2 isolated human populations, the island of Rab and the neighboring islands of Vis and Lastovo, Croatia. The populations were chosen based on previous analyses of genetic diversity and lifestyle patterns, which were shown to be both less diverse and more uniform than the general Croatian population. We studied whether the 25’-75’ and 5-95’ interpercentile ranges in observed values were consistently smaller in 2 samples of 300 examinees from isolated populations in comparison with nearly 6000 examinees from an earlier study who were demographically targeted to represent the larger Croatian population.
Results: General population had much wider range of observed values of triglycerides and HDL than both isolated populations. However, both isolated populations exhibited greater extent of variation in the levels of LDL, while the ranges of cholesterol values were similar.
Conclusion: Although reduced genetic and environmental diversity in isolated human populations should necessarily reduce the variance in observed phenotypic values, it appears that specific population genetic processes in isolated populations could be acting to maintain the variation. Departure from the Hardy-Weinberg equilibrium due to consanguinity, sub-structuring and differentiation within the isolates, and increased rate of new mutations could theoretically explain this paradox.

Ključne riječi
Croatia; human isolates; phenotypic variation; quantitative traits; serum lipids

Hrčak ID: 4386

URI
https://hrcak.srce.hr/4386

Posjeta: 453 *