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Determination of L-Ascorbic Acid in Pharmaceutical Preparations Using Direct Ultraviolet Spectrophotometry

Mirsad Salkić   ORCID icon orcid.org/0000-0002-2540-3784 ; University of Tuzla, Faculty of Technology, Univerzitetska 8, 75000 Tuzla, Bosnia and Herzegovina
Husejin Keran ; University of Tuzla, Faculty of Technology, Univerzitetska 8, 75000 Tuzla, Bosnia and Herzegovina
Midhat Jašić ; University of Tuzla, Faculty of Technology, Univerzitetska 8, 75000 Tuzla, Bosnia and Herzegovina

Puni tekst: engleski, pdf (139 KB) str. 263-268 preuzimanja: 841* citiraj
APA 6th Edition
Salkić, M., Keran, H. i Jašić, M. (2009). Determination of L-Ascorbic Acid in Pharmaceutical Preparations Using Direct Ultraviolet Spectrophotometry. Agriculturae Conspectus Scientificus, 74 (3), 263-268. Preuzeto s https://hrcak.srce.hr/47400
MLA 8th Edition
Salkić, Mirsad, et al. "Determination of L-Ascorbic Acid in Pharmaceutical Preparations Using Direct Ultraviolet Spectrophotometry." Agriculturae Conspectus Scientificus, vol. 74, br. 3, 2009, str. 263-268. https://hrcak.srce.hr/47400. Citirano 21.10.2021.
Chicago 17th Edition
Salkić, Mirsad, Husejin Keran i Midhat Jašić. "Determination of L-Ascorbic Acid in Pharmaceutical Preparations Using Direct Ultraviolet Spectrophotometry." Agriculturae Conspectus Scientificus 74, br. 3 (2009): 263-268. https://hrcak.srce.hr/47400
Harvard
Salkić, M., Keran, H., i Jašić, M. (2009). 'Determination of L-Ascorbic Acid in Pharmaceutical Preparations Using Direct Ultraviolet Spectrophotometry', Agriculturae Conspectus Scientificus, 74(3), str. 263-268. Preuzeto s: https://hrcak.srce.hr/47400 (Datum pristupa: 21.10.2021.)
Vancouver
Salkić M, Keran H, Jašić M. Determination of L-Ascorbic Acid in Pharmaceutical Preparations Using Direct Ultraviolet Spectrophotometry. Agriculturae Conspectus Scientificus [Internet]. 2009 [pristupljeno 21.10.2021.];74(3):263-268. Dostupno na: https://hrcak.srce.hr/47400
IEEE
M. Salkić, H. Keran i M. Jašić, "Determination of L-Ascorbic Acid in Pharmaceutical Preparations Using Direct Ultraviolet Spectrophotometry", Agriculturae Conspectus Scientificus, vol.74, br. 3, str. 263-268, 2009. [Online]. Dostupno na: https://hrcak.srce.hr/47400. [Citirano: 21.10.2021.]

Sažetak
A new, selective and accurate direct ultraviolet spectrophotometric method was developed for the determination of L-ascorbic acid in pharmaceuticals. The oxidation of L-ascorbic acid by iodate in an acidic medium was used as a means of correcting for background absorption. The molar absorptivity of the proposed method was found to be 8.71x103 dm3 mol-1 cm-1 at 250 nm. Beer’s law was obeyed in the concentration range of 0.46 – 16.00 μg cm-3 for L-ascorbic acid. The relative standard deviation was 0.67 % for a concentration of 8.00 μg cm-3 of ascorbic acid (n = 7). The ingredients commonly found in vitamin C and multivitamin products did not interfere. The proposed procedure was successfully applied to assays of L-ascorbic acid in pharmaceutical preparations. The results obtained with the proposed method showed good agreement with those given by the titrimetric method using iodine.

Ključne riječi
L-ascorbic acid; iodate; ultraviolet spectrophotometry

Hrčak ID: 47400

URI
https://hrcak.srce.hr/47400

Posjeta: 1.218 *