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The pharmacogenetics of warfarin in clinical practice

Nada Božina ; Clinical Institute of Laboratory Diagnosis, Zagreb University Hospital Center, Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia

Puni tekst: engleski, pdf (254 KB) str. 33-44 preuzimanja: 308* citiraj
APA 6th Edition
Božina, N. (2010). The pharmacogenetics of warfarin in clinical practice. Biochemia Medica, 20 (1), 33-44. Preuzeto s https://hrcak.srce.hr/47848
MLA 8th Edition
Božina, Nada. "The pharmacogenetics of warfarin in clinical practice." Biochemia Medica, vol. 20, br. 1, 2010, str. 33-44. https://hrcak.srce.hr/47848. Citirano 30.10.2020.
Chicago 17th Edition
Božina, Nada. "The pharmacogenetics of warfarin in clinical practice." Biochemia Medica 20, br. 1 (2010): 33-44. https://hrcak.srce.hr/47848
Harvard
Božina, N. (2010). 'The pharmacogenetics of warfarin in clinical practice', Biochemia Medica, 20(1), str. 33-44. Preuzeto s: https://hrcak.srce.hr/47848 (Datum pristupa: 30.10.2020.)
Vancouver
Božina N. The pharmacogenetics of warfarin in clinical practice. Biochemia Medica [Internet]. 2010 [pristupljeno 30.10.2020.];20(1):33-44. Dostupno na: https://hrcak.srce.hr/47848
IEEE
N. Božina, "The pharmacogenetics of warfarin in clinical practice", Biochemia Medica, vol.20, br. 1, str. 33-44, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/47848. [Citirano: 30.10.2020.]
Puni tekst: hrvatski, pdf (254 KB) str. 33-44 preuzimanja: 446* citiraj
APA 6th Edition
Božina, N. (2010). Farmakogenetika varfarina u kliničkoj praksi. Biochemia Medica, 20 (1), 33-44. Preuzeto s https://hrcak.srce.hr/47848
MLA 8th Edition
Božina, Nada. "Farmakogenetika varfarina u kliničkoj praksi." Biochemia Medica, vol. 20, br. 1, 2010, str. 33-44. https://hrcak.srce.hr/47848. Citirano 30.10.2020.
Chicago 17th Edition
Božina, Nada. "Farmakogenetika varfarina u kliničkoj praksi." Biochemia Medica 20, br. 1 (2010): 33-44. https://hrcak.srce.hr/47848
Harvard
Božina, N. (2010). 'Farmakogenetika varfarina u kliničkoj praksi', Biochemia Medica, 20(1), str. 33-44. Preuzeto s: https://hrcak.srce.hr/47848 (Datum pristupa: 30.10.2020.)
Vancouver
Božina N. Farmakogenetika varfarina u kliničkoj praksi. Biochemia Medica [Internet]. 2010 [pristupljeno 30.10.2020.];20(1):33-44. Dostupno na: https://hrcak.srce.hr/47848
IEEE
N. Božina, "Farmakogenetika varfarina u kliničkoj praksi", Biochemia Medica, vol.20, br. 1, str. 33-44, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/47848. [Citirano: 30.10.2020.]

Sažetak
Warfarin is the most widely prescribed oral anticoagulant. It shows great (up to 20-fold) interindividual variability in dose requirement because of both, genetic and environmental factors. Information from pharmacogenomics, a study of the interaction of the individual's genotype and drug response, can help optimize drug efficacy and minimize adverse drug reactions. Genotyping data on two genes, the warfarin metabolic enzyme CYP2C9 and warfarin target enzyme, vitamin K epoxide reductase complex 1 (VKORC1), confirmed their influence on warfarin maintenance dose. Genome-wide association stu-dy also found a weak effect of CYP4F2. The presence of CYP2C9*2 or CYP2C9*3 variant alleles, which results in decreased enzyme activity, is associated with a significant decrease in the mean warfarin dose. VKORC1 single nucleotide polymorphisms (SNPs) explain a large fraction of the interindividual variation in warfarin dose, and VKORC1 has an approximately three-fold CYP2C9 effect. Carrier state of a combination of VKORC1 and CYP2C9 polymorphisms, rather than of one of these polymorphisms is associated with severe overanticoagulation. The time to achieve stability is mainly associated with the CYP2C9 genotype. Warfarin resistance has been related to several missense mutatio-ns in the VKORC1. Algorithms incorporating genetic (CYP2C9 and VKORC1), de-mographic, and clinical factors to estimate warfarin dosage could potentially minimize the risk of overdose during warfarin induction.

Ključne riječi
pharmacogenomics; warfarin; VKORC1; CYP2C9; dosing algorithm

Hrčak ID: 47848

URI
https://hrcak.srce.hr/47848

[hrvatski]

Posjeta: 1.647 *