hrcak mascot   Srce   HID

Izvorni znanstveni članak

Sinteza N4-(2,4-dimetilfenil) semikarbazona kao inhibitori 4-aminobutirat aminotransferaze

PERUMAL YOGEESWARI
DHARMARAJAN SRIRAM
RATHINASABAPATHY THIRUMURUGAN
LOGANTHA RAMAMOORTHY JEEWANLAL SUNIL JIT JIT
JEGADEESAN VAIGUNDA RAGAVENDRAN
RAMKUMAR KAVYA
KAVYA RAKHRA
VIVEK SARASWAT

Puni tekst: engleski, pdf (97 KB) str. 259-272 preuzimanja: 785* citiraj
APA 6th Edition
YOGEESWARI, P., SRIRAM, D., THIRUMURUGAN, R., JIT, L.R.J.S.J., RAGAVENDRAN, J.V., KAVYA, R., ... SARASWAT, V. (2006). Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors. Acta Pharmaceutica, 56 (3), 259-272. Preuzeto s https://hrcak.srce.hr/4539
MLA 8th Edition
YOGEESWARI, PERUMAL, et al. "Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors." Acta Pharmaceutica, vol. 56, br. 3, 2006, str. 259-272. https://hrcak.srce.hr/4539. Citirano 22.08.2019.
Chicago 17th Edition
YOGEESWARI, PERUMAL, DHARMARAJAN SRIRAM, RATHINASABAPATHY THIRUMURUGAN, LOGANTHA RAMAMOORTHY JEEWANLAL SUNIL JIT JIT, JEGADEESAN VAIGUNDA RAGAVENDRAN, RAMKUMAR KAVYA, KAVYA RAKHRA i VIVEK SARASWAT. "Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors." Acta Pharmaceutica 56, br. 3 (2006): 259-272. https://hrcak.srce.hr/4539
Harvard
YOGEESWARI, P., et al. (2006). 'Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors', Acta Pharmaceutica, 56(3), str. 259-272. Preuzeto s: https://hrcak.srce.hr/4539 (Datum pristupa: 22.08.2019.)
Vancouver
YOGEESWARI P, SRIRAM D, THIRUMURUGAN R, JIT LRJSJ, RAGAVENDRAN JV, KAVYA R i sur. Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors. Acta Pharm. [Internet]. 2006 [pristupljeno 22.08.2019.];56(3):259-272. Dostupno na: https://hrcak.srce.hr/4539
IEEE
P. YOGEESWARI, et al., "Synthesis of N4- (2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors", Acta Pharmaceutica, vol.56, br. 3, str. 259-272, 2006. [Online]. Dostupno na: https://hrcak.srce.hr/4539. [Citirano: 22.08.2019.]

Sažetak
Sintetizirano je nekoliko 2,4-dimetilfenil supstituiranih semikarbazona u tri sintetska koraka koji uključuju aril uree i aril semikarbazide. Strukture spojeva su potvrđene spektroskopskim metoda i elementarnom analizom. Ispitano je antikonvulzivno djelovanje novih spojeva nakon izazivanja konvulzija elektrošokom te supkutanom primjenom pentilentetrazola ili strihnina. Osim toga, testirano je antidepresivno djelovanje te učinak tih spojeva na ponašanje štakora. Praćen je njihov utjecaj na koncentraciju gama-aminomaslačne kiseline (GABA) u mozgu štakora te in vitro na aktivnost gama-aminobutirat transaminaze (Pseudomonas fluorescens). Preliminarni pokusi ukazuju da antikonvulzivno djelovanje ovih spojeva uključuje GABA-ergički sustav.

Ključne riječi
2,4-dimetilfenil semikarbazoni; antikonvulzivi; GABA; GABA-transaminaza; maksimalni elektrošok; pentilentetrazol; strihnin

Hrčak ID: 4539

URI
https://hrcak.srce.hr/4539

[engleski]

Posjeta: 1.189 *