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In vitro drug release of hydrophilic and hydrophobic drug entities from liposomal dispersions and gels

MOHAMED MAHMOUD NOUNOU
LABIBA K. EL-KHORDAGUI
NAWAL A. KHALAFALLAH
SAID A. KHALIL

Puni tekst: engleski, pdf (135 KB) str. 311-324 preuzimanja: 8.710* citiraj
APA 6th Edition
NOUNOU, M.M., EL-KHORDAGUI, L.K., KHALAFALLAH, N.A. i KHALIL, S.A. (2006). In vitro drug release of hydrophilic and hydrophobic drug entities from liposomal dispersions and gels. Acta Pharmaceutica, 56 (3), 311-324. Preuzeto s https://hrcak.srce.hr/4542
MLA 8th Edition
NOUNOU, MOHAMED MAHMOUD, et al. "In vitro drug release of hydrophilic and hydrophobic drug entities from liposomal dispersions and gels." Acta Pharmaceutica, vol. 56, br. 3, 2006, str. 311-324. https://hrcak.srce.hr/4542. Citirano 18.10.2019.
Chicago 17th Edition
NOUNOU, MOHAMED MAHMOUD, LABIBA K. EL-KHORDAGUI, NAWAL A. KHALAFALLAH i SAID A. KHALIL. "In vitro drug release of hydrophilic and hydrophobic drug entities from liposomal dispersions and gels." Acta Pharmaceutica 56, br. 3 (2006): 311-324. https://hrcak.srce.hr/4542
Harvard
NOUNOU, M.M., et al. (2006). 'In vitro drug release of hydrophilic and hydrophobic drug entities from liposomal dispersions and gels', Acta Pharmaceutica, 56(3), str. 311-324. Preuzeto s: https://hrcak.srce.hr/4542 (Datum pristupa: 18.10.2019.)
Vancouver
NOUNOU MM, EL-KHORDAGUI LK, KHALAFALLAH NA, KHALIL SA. In vitro drug release of hydrophilic and hydrophobic drug entities from liposomal dispersions and gels. Acta Pharm. [Internet]. 2006 [pristupljeno 18.10.2019.];56(3):311-324. Dostupno na: https://hrcak.srce.hr/4542
IEEE
M.M. NOUNOU, L.K. EL-KHORDAGUI, N.A. KHALAFALLAH i S.A. KHALIL, "In vitro drug release of hydrophilic and hydrophobic drug entities from liposomal dispersions and gels", Acta Pharmaceutica, vol.56, br. 3, str. 311-324, 2006. [Online]. Dostupno na: https://hrcak.srce.hr/4542. [Citirano: 18.10.2019.]

Sažetak
A method for determining the rate of hydrophilic and hydrophobic drug entities release from different types of liposomal dispersions and gels using a dialysis method is described. Dibucaine base and 5-fluorouracil were used as model drugs for a hydrophobic and hydrophilic drug, respectively. A dialysis technique was employed. Release rates were affected by the rate of rotation of the paddles of the tablet dissolution tester, temperature, and volume of release medium. The method was used to evaluate the in vitro drug release from hydrophilic and hydrophobic drug entities from liposomal dispersions and gels. The in vitro release study of dibucaine base showed no burst effect, while the in vitro release study of 5-fluorouracil showed a clear burst effect with an initial fast release phase followed by a sustained release phase.

Ključne riječi
dibucaine; 5-fluorouracil; in vitro release; release stability; liposomal gel; Higuchi diffusion model

Hrčak ID: 4542

URI
https://hrcak.srce.hr/4542

[hrvatski]

Posjeta: 9.270 *