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Original scientific paper

Effect of the molecular size of carboxymethylcellulose and some polymers on the sustained release of theophylline from a hydrophilic matrix

MARTINS O. EMEJE
OLOBAYO O. KUNLE
SABINUS I. OFOEFULE

Fulltext: english, pdf (108 KB) pages 325-335 downloads: 1.713* cite
APA 6th Edition
EMEJE, M.O., KUNLE, O.O. & OFOEFULE, S.I. (2006). Effect of the molecular size of carboxymethylcellulose and some polymers on the sustained release of theophylline from a hydrophilic matrix. Acta Pharmaceutica, 56 (3), 325-335. Retrieved from https://hrcak.srce.hr/4543
MLA 8th Edition
EMEJE, MARTINS O., et al. "Effect of the molecular size of carboxymethylcellulose and some polymers on the sustained release of theophylline from a hydrophilic matrix." Acta Pharmaceutica, vol. 56, no. 3, 2006, pp. 325-335. https://hrcak.srce.hr/4543. Accessed 23 Jul. 2019.
Chicago 17th Edition
EMEJE, MARTINS O., OLOBAYO O. KUNLE and SABINUS I. OFOEFULE. "Effect of the molecular size of carboxymethylcellulose and some polymers on the sustained release of theophylline from a hydrophilic matrix." Acta Pharmaceutica 56, no. 3 (2006): 325-335. https://hrcak.srce.hr/4543
Harvard
EMEJE, M.O., KUNLE, O.O., and OFOEFULE, S.I. (2006). 'Effect of the molecular size of carboxymethylcellulose and some polymers on the sustained release of theophylline from a hydrophilic matrix', Acta Pharmaceutica, 56(3), pp. 325-335. Available at: https://hrcak.srce.hr/4543 (Accessed 23 July 2019)
Vancouver
EMEJE MO, KUNLE OO, OFOEFULE SI. Effect of the molecular size of carboxymethylcellulose and some polymers on the sustained release of theophylline from a hydrophilic matrix. Acta Pharm. [Internet]. 2006 [cited 2019 July 23];56(3):325-335. Available from: https://hrcak.srce.hr/4543
IEEE
M.O. EMEJE, O.O. KUNLE and S.I. OFOEFULE, "Effect of the molecular size of carboxymethylcellulose and some polymers on the sustained release of theophylline from a hydrophilic matrix", Acta Pharmaceutica, vol.56, no. 3, pp. 325-335, 2006. [Online]. Available: https://hrcak.srce.hr/4543. [Accessed: 23 July 2019]

Abstracts
The objective of this study was to investigate the influence of the molecular size of carboxymethylcellulose (cmc) and some hydrophobic polymer additives on the release properties of theophylline from the tablet matrices. The cmc matrices were prepared by the conventional wet granulation method. The granules were evaluated for angles of repose, bulk density, compressibility index, and porosity, while the tablets were subjected to hardness, friability and compression characteristics. All the tablet formulations showed acceptable pharmacotechnical properties. Low molecular size cmc (cmc-L) had the fastest drug release t50% values of 27 min, for medium size cmc (cmc-M) 55 min and high molecular size cmc (cmc-H) 200 min. Overall, results showed that drug release rate decreases with increase in molecular size of cmc. All the polymer additives ethylcellulose (ETC), cellulose acetate phthalate (CAP) and Eudragit l-100 (EUD) retarded theophylline release from cmc-L and cmc-H, with ethylcellulose having the most pronounced effect on cmc-L. Kinetic studies using Hixson-Crowell and Peppas-Ritger equations showed that different drug release mechanisms were involved in controlling drug dissolution from the tablets. Drug release mechanism was influenced by both the molecular size of cmc and the presence of polymer additives.

Keywords
carboxymethylcellulose; hydrophobic polymers; theophylline; sustained-release; release mechanism

Hrčak ID: 4543

URI
https://hrcak.srce.hr/4543

[croatian]

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