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Original scientific paper

Derivati aminokiselina. Dio 1. Sinteza, antivirusno i antitumorsko djelovanje novih estera alfa-aminokiselina s kumarinskim supstituentom

NAJIM A. AL-MASOUDI
IMAN A. AL-MASOUDI
IBRAHIM A. I. ALI
YASEEN A: AL-SOUD
BAHJAT SAEED
PAOLO LA COLLA

Fulltext: english, pdf (105 KB) pages 175-188 downloads: 1.261* cite
APA 6th Edition
AL-MASOUDI, N.A., AL-MASOUDI, I.A., ALI, I.A.I., AL-SOUD, Y.A., SAEED, B. & LA COLLA, P. (2006). Amino acid derivarives Part 1. Synthesis, antiviral and antitumor evaluation of new alpha-amino acid esters bearing coumarin side chain. Acta Pharmaceutica, 56 (2), 175-188. Retrieved from https://hrcak.srce.hr/4551
MLA 8th Edition
AL-MASOUDI, NAJIM A., et al. "Amino acid derivarives Part 1. Synthesis, antiviral and antitumor evaluation of new alpha-amino acid esters bearing coumarin side chain." Acta Pharmaceutica, vol. 56, no. 2, 2006, pp. 175-188. https://hrcak.srce.hr/4551. Accessed 19 Oct. 2019.
Chicago 17th Edition
AL-MASOUDI, NAJIM A., IMAN A. AL-MASOUDI, IBRAHIM A. I. ALI, YASEEN A: AL-SOUD, BAHJAT SAEED and PAOLO LA COLLA. "Amino acid derivarives Part 1. Synthesis, antiviral and antitumor evaluation of new alpha-amino acid esters bearing coumarin side chain." Acta Pharmaceutica 56, no. 2 (2006): 175-188. https://hrcak.srce.hr/4551
Harvard
AL-MASOUDI, N.A., et al. (2006). 'Amino acid derivarives Part 1. Synthesis, antiviral and antitumor evaluation of new alpha-amino acid esters bearing coumarin side chain', Acta Pharmaceutica, 56(2), pp. 175-188. Available at: https://hrcak.srce.hr/4551 (Accessed 19 October 2019)
Vancouver
AL-MASOUDI NA, AL-MASOUDI IA, ALI IAI, AL-SOUD YA, SAEED B, LA COLLA P. Amino acid derivarives Part 1. Synthesis, antiviral and antitumor evaluation of new alpha-amino acid esters bearing coumarin side chain. Acta Pharm. [Internet]. 2006 [cited 2019 October 19];56(2):175-188. Available from: https://hrcak.srce.hr/4551
IEEE
N.A. AL-MASOUDI, I.A. AL-MASOUDI, I.A.I. ALI, Y.A. AL-SOUD, B. SAEED and P. LA COLLA, "Amino acid derivarives Part 1. Synthesis, antiviral and antitumor evaluation of new alpha-amino acid esters bearing coumarin side chain", Acta Pharmaceutica, vol.56, no. 2, pp. 175-188, 2006. [Online]. Available: https://hrcak.srce.hr/4551. [Accessed: 19 October 2019]

Abstracts
U radu je opisana sinteza estera aminokiselina s kumarinskim ostatkom 3-15. Ispitano je antivirusno djelovanje sintetiziranih spojeva na HIV-1 i goveđi virus diareje (BVDV) te in vitro citotoksičnost spojeva 3-10 i 12 na tumorskim linijama CD4 humanih T-stanica. Spoj 14 pokazao je inhibiciju HIV-1 s EC50 > 1.6 microg mL-1, dok je spoj 9 djelotvoran na leukemiju (MT4) s CC50 = 24 micromol L-1.

Keywords
aminokiseline; antitumorsko djelovanje; antivirusno djelovanje; kumarin

Hrčak ID: 4551

URI
https://hrcak.srce.hr/4551

[english]

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