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https://doi.org/10.2478/v10007-010-0004-0

Synthesis and biological activity of some new 1-benzyl and 1-benzoyl 3-heterocyclic indole derivatives

ESLAM REDA EL-SAWY ; Chemistry Department of Natural Compounds, National Research Centre, Cairo, Egypt
FATMA A. BASSYOUNI ; Chemistry Department of Natural and Microbial Products, National Research Centre, Cairo, Egypt
SHERIFA H. ABU-BAKR ; Chemistry Department of Natural and Microbial Products, National Research Centre, Cairo, Egypt
HANAA M. RADY ; Chemistry Department of Natural Compounds, National Research Centre, Cairo, Egypt
MOHAMED M. ABDLLA ; Univeterinary Research Unit, Pharmaceutical Company, Cairo, Egypt

Puni tekst: engleski, pdf (108 KB) str. 55-71 preuzimanja: 1.045* citiraj
APA 6th Edition
EL-SAWY, E.R., BASSYOUNI, F.A., ABU-BAKR, S.H., RADY, H.M. i ABDLLA, M.M. (2010). Synthesis and biological activity of some new 1-benzyl and 1-benzoyl 3-heterocyclic indole derivatives. Acta Pharmaceutica, 60 (1), 55-71. https://doi.org/10.2478/v10007-010-0004-0
MLA 8th Edition
EL-SAWY, ESLAM REDA, et al. "Synthesis and biological activity of some new 1-benzyl and 1-benzoyl 3-heterocyclic indole derivatives." Acta Pharmaceutica, vol. 60, br. 1, 2010, str. 55-71. https://doi.org/10.2478/v10007-010-0004-0. Citirano 21.11.2019.
Chicago 17th Edition
EL-SAWY, ESLAM REDA, FATMA A. BASSYOUNI, SHERIFA H. ABU-BAKR, HANAA M. RADY i MOHAMED M. ABDLLA. "Synthesis and biological activity of some new 1-benzyl and 1-benzoyl 3-heterocyclic indole derivatives." Acta Pharmaceutica 60, br. 1 (2010): 55-71. https://doi.org/10.2478/v10007-010-0004-0
Harvard
EL-SAWY, E.R., et al. (2010). 'Synthesis and biological activity of some new 1-benzyl and 1-benzoyl 3-heterocyclic indole derivatives', Acta Pharmaceutica, 60(1), str. 55-71. https://doi.org/10.2478/v10007-010-0004-0
Vancouver
EL-SAWY ER, BASSYOUNI FA, ABU-BAKR SH, RADY HM, ABDLLA MM. Synthesis and biological activity of some new 1-benzyl and 1-benzoyl 3-heterocyclic indole derivatives. Acta Pharm. [Internet]. 2010 [pristupljeno 21.11.2019.];60(1):55-71. https://doi.org/10.2478/v10007-010-0004-0
IEEE
E.R. EL-SAWY, F.A. BASSYOUNI, S.H. ABU-BAKR, H.M. RADY i M.M. ABDLLA, "Synthesis and biological activity of some new 1-benzyl and 1-benzoyl 3-heterocyclic indole derivatives", Acta Pharmaceutica, vol.60, br. 1, str. 55-71, 2010. [Online]. https://doi.org/10.2478/v10007-010-0004-0

Sažetak
Starting from 1-benzyl- (2a) and 1-benzoyl-3-bromoacetyl indoles (2b) new heterocyclic, 2-thioxoimidazolidine (4a,b), imidazolidine-2,4-dione (5a,b), pyrano(2,3-d)imidazole (8a,b and 9a,b), 2-substituted quinoxaline (11a,b–17a,b) and triazolo(4,3-a)quinoxaline derivatives (18a,b and 19a,b) were synthesized and evaluated for their antimicrobial and anticancer activities. Antimicrobial activity screening performed with concentrations of 0.88, 0.44 and 0.22 g mm2 showed that 3-(1-substituted indol-3-yl)quinoxalin-2(1H)ones (11a,b) and 2-(4-methyl piperazin-1-yl)-3-(1-substituted indol-3-yl) quinoxalines (15a,b) were the most active of all the tested compounds towards P. aeruginosa, B. cereus and S. aureus compared to the reference drugs cefotaxime and piperacillin, while 2-chloro-3-(1-substituted indol-3-yl)quinoxalines (12a,b) were the most active against C. albicans compared to the reference drug nystatin. On the other hand, 2-chloro-3-(1-benzyl indol-3-yl) quinoxaline (12a) display potent efficacy against ovarian cancer xenografts in nude mice with tumor growth suppression of 100  0.3 %.

Ključne riječi
2-chloro-3-(1-benzyl)quinoxalines; 2-chloro-3-(1-benzoylindol-3-yl)quinoxalines; antimicrobial; ovarian anti-cancer

Hrčak ID: 48278

URI
https://hrcak.srce.hr/48278

[hrvatski]

Posjeta: 1.351 *