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Kratko priopćenje
https://doi.org/10.2478/v10007-010-0005-z

Priprava i vrednovanje biorazgradljivih implantata s kontroliranim oslobađanjem za postoperativnu primjenu

VIJAY MATHUR ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India
RAJESH MUDNAIK ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India
LAXMIKANT BARDE ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India
ARGHYA ROY ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India
UMESH SHIVHARE ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India
KISHORE BHUSARI ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India

Puni tekst: engleski, pdf (70 KB) str. 111-117 preuzimanja: 1.519* citiraj
APA 6th Edition
MATHUR, V., MUDNAIK, R., BARDE, L., ROY, A., SHIVHARE, U. i BHUSARI, K. (2010). Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery. Acta Pharmaceutica, 60 (1), 111-117. https://doi.org/10.2478/v10007-010-0005-z
MLA 8th Edition
MATHUR, VIJAY, et al. "Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery." Acta Pharmaceutica, vol. 60, br. 1, 2010, str. 111-117. https://doi.org/10.2478/v10007-010-0005-z. Citirano 17.06.2019.
Chicago 17th Edition
MATHUR, VIJAY, RAJESH MUDNAIK, LAXMIKANT BARDE, ARGHYA ROY, UMESH SHIVHARE i KISHORE BHUSARI. "Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery." Acta Pharmaceutica 60, br. 1 (2010): 111-117. https://doi.org/10.2478/v10007-010-0005-z
Harvard
MATHUR, V., et al. (2010). 'Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery', Acta Pharmaceutica, 60(1), str. 111-117. doi: https://doi.org/10.2478/v10007-010-0005-z
Vancouver
MATHUR V, MUDNAIK R, BARDE L, ROY A, SHIVHARE U, BHUSARI K. Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery. Acta Pharm. [Internet]. 2010 [pristupljeno 17.06.2019.];60(1):111-117. doi: https://doi.org/10.2478/v10007-010-0005-z
IEEE
V. MATHUR, R. MUDNAIK, L. BARDE, A. ROY, U. SHIVHARE i K. BHUSARI, "Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery", Acta Pharmaceutica, vol.60, br. 1, str. 111-117, 2010. [Online]. doi: https://doi.org/10.2478/v10007-010-0005-z

Sažetak
Biorazgradljivi implantati ciprofloksacin hidroklorida za postoperativnu primjenu pripravljeni su pomoću gliceril monostearata (GMS) i različitih koncentracija polietilen glikola (PEG 6000), glicerola i Tween 80 kao promotora erozije metodom kompresije i lijevanja. Oslobađanje ljekovite tvari iz pripravaka praćeno je in vitro prema USP metodi. Pripravci koji su dali dobre rezultate ispitani su i in vitro metodom s agarom te su podvrgnuti testovima stabilnosti. Primijećeno je da gliceril monostearat tvori hidrofobni matriks i usporava oslobađanje lijeka. Koristeći različite kombinacije promotora erozije postignuto je kontrolirano oslobađanje antibiotika. Oslobađanje iz implantata dobivenih metodom kompresije sporije je od implantata dobivenih metodom lijevanja.

Ključne riječi
biorazgradljivi implantati antibiotika; gliceril monostearat; kontrolirano oslobađanje; mjesto isporuke; promotor erozije

Hrčak ID: 48279

URI
https://hrcak.srce.hr/48279

[engleski]

Posjeta: 1.794 *