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Kratko priopćenje
https://doi.org/10.2478/v10007-010-0005-z

Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery

VIJAY MATHUR ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India
RAJESH MUDNAIK ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India
LAXMIKANT BARDE ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India
ARGHYA ROY ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India
UMESH SHIVHARE ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India
KISHORE BHUSARI ; Sharad Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India

Puni tekst: engleski, pdf (70 KB) str. 111-117 preuzimanja: 1.519* citiraj
APA 6th Edition
MATHUR, V., MUDNAIK, R., BARDE, L., ROY, A., SHIVHARE, U. i BHUSARI, K. (2010). Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery. Acta Pharmaceutica, 60 (1), 111-117. https://doi.org/10.2478/v10007-010-0005-z
MLA 8th Edition
MATHUR, VIJAY, et al. "Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery." Acta Pharmaceutica, vol. 60, br. 1, 2010, str. 111-117. https://doi.org/10.2478/v10007-010-0005-z. Citirano 17.06.2019.
Chicago 17th Edition
MATHUR, VIJAY, RAJESH MUDNAIK, LAXMIKANT BARDE, ARGHYA ROY, UMESH SHIVHARE i KISHORE BHUSARI. "Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery." Acta Pharmaceutica 60, br. 1 (2010): 111-117. https://doi.org/10.2478/v10007-010-0005-z
Harvard
MATHUR, V., et al. (2010). 'Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery', Acta Pharmaceutica, 60(1), str. 111-117. doi: https://doi.org/10.2478/v10007-010-0005-z
Vancouver
MATHUR V, MUDNAIK R, BARDE L, ROY A, SHIVHARE U, BHUSARI K. Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery. Acta Pharm. [Internet]. 2010 [pristupljeno 17.06.2019.];60(1):111-117. doi: https://doi.org/10.2478/v10007-010-0005-z
IEEE
V. MATHUR, R. MUDNAIK, L. BARDE, A. ROY, U. SHIVHARE i K. BHUSARI, "Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery", Acta Pharmaceutica, vol.60, br. 1, str. 111-117, 2010. [Online]. doi: https://doi.org/10.2478/v10007-010-0005-z

Sažetak
Biodegradable implants of ciprofloxacin hydrochloride for post operative site delivery were prepared using glyceryl monostearate and different concentrations of polyethylene glycol (PEG 6000) glycerol and Tween 80 as erosion enhancers by compression and molding technique. Formulations were subjected to in vitro drug release by the USP dissolution method, while promising formulations were subjected to in vitro drug release by the agar gel method and also to stability studies. It was observed that glyceryl monostearate formed hydrophobic matrix and delayed the drug delivery. Antibiotic release profile was controlled by using different combinations of erosion enhancers. The formulation prepared by compression method showed more delayed release as compared to formulations prepared by molding method.

Ključne riječi
biodegradable antibiotic implants; glyceryl monostearate; controlled drug release; site delivery; erosion enhancers

Hrčak ID: 48279

URI
https://hrcak.srce.hr/48279

[hrvatski]

Posjeta: 1.794 *