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Short communication, Note
https://doi.org/10.2478/v10007-010-0006-y

Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity

NATALIA WSZELAKI ; Institute of Pharmacy, Free University of Berlin, D-14195 Berlin, Germany
AGNIESZKA KUCIUN ; Department of Pharmacognosy and Molecular Basis of Phytotherapy, Faculty of Pharmacy, Medical University of Warsaw, 02-098 Warsaw, Poland
ANNA KAROLINA KISS ; Department of Pharmacognosy and Molecular Basis of Phytotherapy, Faculty of Pharmacy, Medical University of Warsaw, 02-098 Warsaw, Poland

Fulltext: english, pdf (87 KB) pages 119-128 downloads: 1.133* cite
APA 6th Edition
WSZELAKI, N., KUCIUN, A. & KISS, A.K. (2010). Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity. Acta Pharmaceutica, 60 (1), 119-128. https://doi.org/10.2478/v10007-010-0006-y
MLA 8th Edition
WSZELAKI, NATALIA, et al. "Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity." Acta Pharmaceutica, vol. 60, no. 1, 2010, pp. 119-128. https://doi.org/10.2478/v10007-010-0006-y. Accessed 22 Jul. 2019.
Chicago 17th Edition
WSZELAKI, NATALIA, AGNIESZKA KUCIUN and ANNA KAROLINA KISS. "Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity." Acta Pharmaceutica 60, no. 1 (2010): 119-128. https://doi.org/10.2478/v10007-010-0006-y
Harvard
WSZELAKI, N., KUCIUN, A., and KISS, A.K. (2010). 'Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity', Acta Pharmaceutica, 60(1), pp. 119-128. https://doi.org/10.2478/v10007-010-0006-y
Vancouver
WSZELAKI N, KUCIUN A, KISS AK. Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity. Acta Pharm. [Internet]. 2010 [cited 2019 July 22];60(1):119-128. https://doi.org/10.2478/v10007-010-0006-y
IEEE
N. WSZELAKI, A. KUCIUN and A.K. KISS, "Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity", Acta Pharmaceutica, vol.60, no. 1, pp. 119-128, 2010. [Online]. https://doi.org/10.2478/v10007-010-0006-y

Abstracts
Acetylcholinesterase (AChE) inhibitors are widely used for the symptomatic treatment of Alzheimer’s disease (AD) to enhance central cholinergic transmission. On the other hand, butyrylcholinesterase (BuChE) inhibitors were reported to produce significant increases in brain extracellular AChE without triggering severe peripheral or central side-effects. In the present study, we selected twelve plants used in traditional European medicine to treat different central nervous system (CNS) disorders or to improve memory.
Methanolic and hexane extracts of these plants were tested for the AChE and BuChE inhibitory activity using Ellman’s colorimetric method. The most potent AChE and BuChE inhibition was observed in the hexane extracts of the flowers of Arnica chamissonis Less. susb. foliosa and Ruta graveolens L. herb at a concentration of 400 μg mL1. However, methanolic extracts of the flowers of Arnica chamissonis Less. susb. foliosa and the Hypericum perforatum L. herb demonstrated at the same concentration, selective inhibition only against AChE but not against BuChE. The other extracts did not show any significant AChE or BuChE inhibitory activity. Our results show that further investigations of the extracts of arnica, rue and St. John’s Wort are needed to identify the compounds responsible for the AChE and BuChE inhibitory activity

Keywords
acetylcholinesterase inhibition; butyrylcholinesterase inhibition; traditional medicine

Hrčak ID: 48280

URI
https://hrcak.srce.hr/48280

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