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Original scientific paper
https://doi.org/10.2478/v10007-010-0009-8

Sinteza, protuupalno, analgetsko i antikonvulzivno djelovanje 1,8-dihidro-1-aril-8-alkil pirazolo(3,4-b)indola

ADEL H. MANDOUR ; Chemistry Department of Natural Compounds, National Research Centre, Gizza, Egypt
ESLAM R. EL-SAWY ; Chemistry Department of Natural Compounds, National Research Centre, Gizza, Egypt
KAMEL H. SHAKER ; Organic Chemistry NWII,1/2, University of Bayreuth, Bayreuth, Germany
MOHAMED A. MUSTAFA ; Research Unit, Egypt Pharmacist Co., Cairo, Egypt

Fulltext: english, pdf (102 KB) pages 73-88 downloads: 742* cite
APA 6th Edition
MANDOUR, A.H., EL-SAWY, E.R., SHAKER, K.H. & MUSTAFA, M.A. (2010). Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles. Acta Pharmaceutica, 60 (1), 73-88. https://doi.org/10.2478/v10007-010-0009-8
MLA 8th Edition
MANDOUR, ADEL H., et al. "Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles." Acta Pharmaceutica, vol. 60, no. 1, 2010, pp. 73-88. https://doi.org/10.2478/v10007-010-0009-8. Accessed 22 Oct. 2019.
Chicago 17th Edition
MANDOUR, ADEL H., ESLAM R. EL-SAWY, KAMEL H. SHAKER and MOHAMED A. MUSTAFA. "Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles." Acta Pharmaceutica 60, no. 1 (2010): 73-88. https://doi.org/10.2478/v10007-010-0009-8
Harvard
MANDOUR, A.H., et al. (2010). 'Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles', Acta Pharmaceutica, 60(1), pp. 73-88. https://doi.org/10.2478/v10007-010-0009-8
Vancouver
MANDOUR AH, EL-SAWY ER, SHAKER KH, MUSTAFA MA. Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles. Acta Pharm. [Internet]. 2010 [cited 2019 October 22];60(1):73-88. https://doi.org/10.2478/v10007-010-0009-8
IEEE
A.H. MANDOUR, E.R. EL-SAWY, K.H. SHAKER and M.A. MUSTAFA, "Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles", Acta Pharmaceutica, vol.60, no. 1, pp. 73-88, 2010. [Online]. https://doi.org/10.2478/v10007-010-0009-8

Abstracts
Serija 1,8-dihidro-1-aril-8-alkil pirazolo(3,4-b)indola 4a-j, 5a-j i 6a-j sintetizirana je i testirana na protuupalno i antikonvulzivno djelovanje. Pirazolindol derivati pripravljeni su reakcijom arilhidrazona N-alkil indol-3-karboksaldehida 1a-j, 2a-j i 3a-j s deset puta većom masom polifosforne kiseline kao sredstva za kondenzaciju. Novosintetizirani spojevi testirani su na protuupalno, analgetsko i antikonvulzivno djelovanje i uspoređeni s djelovanjem indometacina, flufenaminske kiseline i diazepama. U radu su dati detaljni sintetski, spektroskopski i toksikološki podaci.

Keywords
indol-3-karboksaldehid; protuupalno djelovanje; antikonvulzivno djelovanje; analgetsko djelovanje

Hrčak ID: 48283

URI
https://hrcak.srce.hr/48283

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