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Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether

BOIKA TSVETKOVA
JASMINA TENCHEVA
PLAMEN PEIKOV

Puni tekst: engleski, pdf (116 KB) str. 251-257 preuzimanja: 1.910* citiraj
APA 6th Edition
TSVETKOVA, B., TENCHEVA, J. i PEIKOV, P. (2006). Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether. Acta Pharmaceutica, 56 (2), 251-257. Preuzeto s https://hrcak.srce.hr/4560
MLA 8th Edition
TSVETKOVA, BOIKA, et al. "Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether." Acta Pharmaceutica, vol. 56, br. 2, 2006, str. 251-257. https://hrcak.srce.hr/4560. Citirano 19.10.2019.
Chicago 17th Edition
TSVETKOVA, BOIKA, JASMINA TENCHEVA i PLAMEN PEIKOV. "Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether." Acta Pharmaceutica 56, br. 2 (2006): 251-257. https://hrcak.srce.hr/4560
Harvard
TSVETKOVA, B., TENCHEVA, J., i PEIKOV, P. (2006). 'Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether', Acta Pharmaceutica, 56(2), str. 251-257. Preuzeto s: https://hrcak.srce.hr/4560 (Datum pristupa: 19.10.2019.)
Vancouver
TSVETKOVA B, TENCHEVA J, PEIKOV P. Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether. Acta Pharm. [Internet]. 2006 [pristupljeno 19.10.2019.];56(2):251-257. Dostupno na: https://hrcak.srce.hr/4560
IEEE
B. TSVETKOVA, J. TENCHEVA i P. PEIKOV, "Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether", Acta Pharmaceutica, vol.56, br. 2, str. 251-257, 2006. [Online]. Dostupno na: https://hrcak.srce.hr/4560. [Citirano: 19.10.2019.]

Sažetak
The kinetics of еsterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether in the presence of dicyclohexylcarbodiimide and 4-dimethylaminopyridine as catalyst was studied. According to the known mechanism, besides the main process, the side-reaction of intramolecular rearrangement with formation of pharmacologically active N-acylurea occurs. The course of the main and the side-process was monitored by RP-HPLC with UV-detection. For that purpose, quantification of both ester and N-acylurea in the reaction mixture was performed. Influence of the concentration of the reactants (acid, alcohol and catalyst) on the progress of esterification and preparation of the by-product was investigated. Based on the obtained results, the reaction conditions leading to maximal yield of the ester and N-acylurea are proposed. Possibility of turning esterification to the synthesis of the side-product was also found. Reactions of the preparation of both the ester and N-acylurea were found to follow first-order kinetics. The rate constants of both processes were estimated.

Ključne riječi
7-theophyllineacetic acid ester; N-acylurea; dicyclohexylcarbodiimide; 4-dimethylaminopyridine; esterification; kinetics

Hrčak ID: 4560

URI
https://hrcak.srce.hr/4560

[hrvatski]

Posjeta: 2.718 *