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Acta Pharmaceutica, Vol. 60 No. 2, 2010.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-010-0017-8

Istodobno spektrofotometrijsko određivanje losartan kalija, amlodipin besilata i hidroklorotiazida u farmaceutskim pripravcima kemometrijskom metodom

D. Nagavalli ; Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur-603319, Kanchipuram District, Tamil Nadu, India
V. Vaidhyalingam ; Madras Medical College, Chennai-600003, India
A. Santha ; C. L. Baid Metha College of Pharmacy, Chennai-600 096. Tamil Nadu, India
A. S. K. Sankar ; Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur-603319, Kanchipuram District, Tamil Nadu, India
O. Divya ; IIT, Chennai-600 036, Tamil Nadu, India

Puni tekst: engleski, pdf (104 KB) str. 141-152 preuzimanja: 1.723* citiraj
APA 6th Edition
Nagavalli, D., Vaidhyalingam, V., Santha, A., Sankar, A.S.K. i Divya, O. (2010). Simultaneous spectrophotometric determination of losartan potassium, amlodipine besilate and hydrochlorothiazide in pharmaceuticals by chemometric methods. Acta Pharmaceutica, 60 (2), 141-152. https://doi.org/10.2478/v10007-010-0017-8
MLA 8th Edition
Nagavalli, D., et al. "Simultaneous spectrophotometric determination of losartan potassium, amlodipine besilate and hydrochlorothiazide in pharmaceuticals by chemometric methods." Acta Pharmaceutica, vol. 60, br. 2, 2010, str. 141-152. https://doi.org/10.2478/v10007-010-0017-8. Citirano 18.02.2019.
Chicago 17th Edition
Nagavalli, D., V. Vaidhyalingam, A. Santha, A. S. K. Sankar i O. Divya. "Simultaneous spectrophotometric determination of losartan potassium, amlodipine besilate and hydrochlorothiazide in pharmaceuticals by chemometric methods." Acta Pharmaceutica 60, br. 2 (2010): 141-152. https://doi.org/10.2478/v10007-010-0017-8
Harvard
Nagavalli, D., et al. (2010). 'Simultaneous spectrophotometric determination of losartan potassium, amlodipine besilate and hydrochlorothiazide in pharmaceuticals by chemometric methods', Acta Pharmaceutica, 60(2), str. 141-152. doi: https://doi.org/10.2478/v10007-010-0017-8
Vancouver
Nagavalli D, Vaidhyalingam V, Santha A, Sankar ASK, Divya O. Simultaneous spectrophotometric determination of losartan potassium, amlodipine besilate and hydrochlorothiazide in pharmaceuticals by chemometric methods. Acta Pharm. [Internet]. 2010 [pristupljeno 18.02.2019.];60(2):141-152. doi: https://doi.org/10.2478/v10007-010-0017-8
IEEE
D. Nagavalli, V. Vaidhyalingam, A. Santha, A.S.K. Sankar i O. Divya, "Simultaneous spectrophotometric determination of losartan potassium, amlodipine besilate and hydrochlorothiazide in pharmaceuticals by chemometric methods", Acta Pharmaceutica, vol.60, br. 2, str. 141-152, 2010. [Online]. doi: https://doi.org/10.2478/v10007-010-0017-8

Sažetak
U radu su opisane četiri spektrofotometrijske metode za istodobno određivanje losartan kalija, amlodipin besilata i hidroklorotiazida u sirovinama i farmaceutskim pripravcima. Podaci koji su se preklapali kvantitativno su razlučeni kemometrijskim metodama, klasičnom metodom najmanjih kvadrata (CLS), multiplom linearnom regresijom (MLR), regresijom glavnih komponenata (PCR) te metodom parcijalnih najmanjih kvadrata (PLS). Kalibracije su provedene koristeći podatke o ovisnosti apsorpcije o koncentracijama, mjereći spektre nultog reda u rasponu 230,5350,4 nm (∆λ = 0,1 nm). Linearnost za losartan kalij bila je 840, za amlodipin besilat 15, a za hidroklorotiazid 315 μg ml1. Valjanost predloženih metoda uspješno je potvrđena analizom navedenih lijekova u različitim pripremljenim smjesama i tabletama.

Ključne riječi
losartan; amlodipin besilat; hidroklorotiazid; spektrofotometrija; kemometrija

Hrčak ID: 48383

URI
https://hrcak.srce.hr/48383

[engleski]

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