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Kratko priopćenje
https://doi.org/10.2478/v10007-010-0015-x

Upotreba N,N-dietil-p-fenilenediamin sulfata za spektrofotometrijsko određivanje lijekova iz skupine fenola i amina

Padmarajaiah Nagaraja ; Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570006, India
Ashwinee Kumar Shrestha ; Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570006, India
Anantharaman Shivakumar ; Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570006, India
Avinash K. Gowda ; Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570006, India

Puni tekst: engleski, pdf (127 KB) str. 217-227 preuzimanja: 1.315* citiraj
APA 6th Edition
Nagaraja, P., Shrestha, A.K., Shivakumar, A. i Gowda, A.K. (2010). Use of N,N-diethyl-p-phenylenediamine sulphate for the spectrophotometric determination of some phenolic and amine drugs. Acta Pharmaceutica, 60 (2), 217-227. https://doi.org/10.2478/v10007-010-0015-x
MLA 8th Edition
Nagaraja, Padmarajaiah, et al. "Use of N,N-diethyl-p-phenylenediamine sulphate for the spectrophotometric determination of some phenolic and amine drugs." Acta Pharmaceutica, vol. 60, br. 2, 2010, str. 217-227. https://doi.org/10.2478/v10007-010-0015-x. Citirano 27.06.2019.
Chicago 17th Edition
Nagaraja, Padmarajaiah, Ashwinee Kumar Shrestha, Anantharaman Shivakumar i Avinash K. Gowda. "Use of N,N-diethyl-p-phenylenediamine sulphate for the spectrophotometric determination of some phenolic and amine drugs." Acta Pharmaceutica 60, br. 2 (2010): 217-227. https://doi.org/10.2478/v10007-010-0015-x
Harvard
Nagaraja, P., et al. (2010). 'Use of N,N-diethyl-p-phenylenediamine sulphate for the spectrophotometric determination of some phenolic and amine drugs', Acta Pharmaceutica, 60(2), str. 217-227. doi: https://doi.org/10.2478/v10007-010-0015-x
Vancouver
Nagaraja P, Shrestha AK, Shivakumar A, Gowda AK. Use of N,N-diethyl-p-phenylenediamine sulphate for the spectrophotometric determination of some phenolic and amine drugs. Acta Pharm. [Internet]. 2010 [pristupljeno 27.06.2019.];60(2):217-227. doi: https://doi.org/10.2478/v10007-010-0015-x
IEEE
P. Nagaraja, A.K. Shrestha, A. Shivakumar i A.K. Gowda, "Use of N,N-diethyl-p-phenylenediamine sulphate for the spectrophotometric determination of some phenolic and amine drugs", Acta Pharmaceutica, vol.60, br. 2, str. 217-227, 2010. [Online]. doi: https://doi.org/10.2478/v10007-010-0015-x

Sažetak
U radu je predložena spektrofotometrijska metoda za određivanje lijekova s fenolnom skupinom salbutamol sulfat (SLB), ritodrin hidroklorid (RTD), izoksuprin hidroklorid (IXP) i lijekova s aromatskom amino skupinom dapson hidroklorid (DAP), sulfametoksazol (SFM) i sulfadiazin (SFD) u farmaceutskim dozirnim pripravcima. Metode se temelje na reakciji ljekovitih tvari s N,N-dietil-p-fenilendiamin sulfatom u prisutnosti KIO4, pri čemu nastaje zeleni (λmax pri 670 nm), odnosno crveni produkt (λmax pri 550 nm). Apsorbancije linerano ovise o koncentrancijama lijekova uz visok koeficijent korelacije (0,99860,9996) u koncentracijskom području 17, 222, 117, 1,512, 225 i 221 μg mL1 za SLB, RTD, IXP, DAP, SFM i SFD. Analizirani su i optimirani promjenjivi parametri kao što su temperatura, reakcijsko vrijeme i koncentracija reaktanata. Repetibilnost i intermedijarna preciznost iznosile su 0,21,0, odnosno 0,41,0 %. Nije primjećena nikakva interferencija s uobičajenim farmaceutskim pomoćnim sredstvima. Pouzdanost i izvedbene značajke predložene metode validirane su statistički. Povrat analitičke metode bio je od 99,5 ± 0,1 do 99,9 ± 0,3 %. Granice detekcije bile su 0,14, 0,21, 0,51, 0,44, 0,33 i 0,37 µg mL1 za SLB, RTD, IXP, DAP, SFM, odnosno SFD.

Ključne riječi
N,N-dietil-p-fenilenediamin sulfat; UV/Vis spektrofotometrija; oksidacija; reakcija konjugacije

Hrčak ID: 48385

URI
https://hrcak.srce.hr/48385

[engleski]

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