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Acta Pharmaceutica, Vol. 60 No. 2, 2010.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-010-0016-9

Development of directly compressible metformin hydrochloride by spray drying technique

Bhavesh S. Barot ; K. B. Institute of Pharmaceutical Education and Research, Gh-6 Road, Sector – 23, Gandhinagar-382023, Gujarat, India
Punit B. Parejiya ; K. B. Institute of Pharmaceutical Education and Research, Gh-6 Road, Sector – 23, Gandhinagar-382023, Gujarat, India
Tushar M. Patel ; L. M. College of Pharmacy, Opp. Gujarat University, Navrangpura, Ahmedabad-380009
Rajesh K. Parikh ; L. M. College of Pharmacy, Opp. Gujarat University, Navrangpura, Ahmedabad-380009
Mukesh C. Gohel ; L. M. College of Pharmacy, Opp. Gujarat University, Navrangpura, Ahmedabad-380009

Puni tekst: engleski, pdf (121 KB) str. 165-175 preuzimanja: 2.036* citiraj
APA 6th Edition
Barot, B.S., Parejiya, P.B., Patel, T.M., Parikh, R.K. i Gohel, M.C. (2010). Development of directly compressible metformin hydrochloride by spray drying technique. Acta Pharmaceutica, 60 (2), 165-175. https://doi.org/10.2478/v10007-010-0016-9
MLA 8th Edition
Barot, Bhavesh S., et al. "Development of directly compressible metformin hydrochloride by spray drying technique." Acta Pharmaceutica, vol. 60, br. 2, 2010, str. 165-175. https://doi.org/10.2478/v10007-010-0016-9. Citirano 19.02.2019.
Chicago 17th Edition
Barot, Bhavesh S., Punit B. Parejiya, Tushar M. Patel, Rajesh K. Parikh i Mukesh C. Gohel. "Development of directly compressible metformin hydrochloride by spray drying technique." Acta Pharmaceutica 60, br. 2 (2010): 165-175. https://doi.org/10.2478/v10007-010-0016-9
Harvard
Barot, B.S., et al. (2010). 'Development of directly compressible metformin hydrochloride by spray drying technique', Acta Pharmaceutica, 60(2), str. 165-175. doi: https://doi.org/10.2478/v10007-010-0016-9
Vancouver
Barot BS, Parejiya PB, Patel TM, Parikh RK, Gohel MC. Development of directly compressible metformin hydrochloride by spray drying technique. Acta Pharm. [Internet]. 2010 [pristupljeno 19.02.2019.];60(2):165-175. doi: https://doi.org/10.2478/v10007-010-0016-9
IEEE
B.S. Barot, P.B. Parejiya, T.M. Patel, R.K. Parikh i M.C. Gohel, "Development of directly compressible metformin hydrochloride by spray drying technique", Acta Pharmaceutica, vol.60, br. 2, str. 165-175, 2010. [Online]. doi: https://doi.org/10.2478/v10007-010-0016-9

Sažetak
Metformin hydrochloride exhibits poor compressibility during compaction, often resulting in weak and unacceptable tablets with a high tendency to cap. The purpose of this study was to develop directly compressible metformin hydrochloride by the spray drying technique in the presence of polymer. Metformin hydrochloride was dissolved in solutions containing a polymer, namely polyvinylpyrrolidone (PVP K30), in various concentrations ranging from 0-3 % m/V. These solutions were employed for spray-drying. Spray-dried drug was evaluated for yield, flow property and compressibility profile. Metformin hydrochloride spray-dried in the presence of 2 % PVP K30 showed an excellent flow property and compressibility profile. From the calculated Heckel’s parameter (Py = 2.086), it was demonstrated that the treated drug showed better particle arrangement in the initial compression stage. Kawakita analysis revealed better packability of the treated drug compared to the untreated drug. Differential scanning calorimetry and Fourier transform infrared spectroscopy experiments showed that the spray-dried drug did not undergo any chemical modifications. Tablets made from the spray-dried drug (90 %, m/m) were evaluated for crushing strength, friability and disintegration time and the results were found satisfactory.

Ključne riječi
metformin hydrochloride; direct compression; spray drying

Hrčak ID: 48389

URI
https://hrcak.srce.hr/48389

[hrvatski]

Posjeta: 2.504 *