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Arhiv za higijenu rada i toksikologiju, Vol. 61 No. 1, 2010.

Kratko priopćenje
https://doi.org/10.2478/10004-1254-61-2010-1982

Dose Rate Effect of Pulsed Electron Beam on Micronucleus Frequency in Human Peripheral Blood Lymphocytes

Santhosh Acharya ; Microtron Centre, Department of Studies in Physics, Mangalore University, Mangalagangotri, India
Ganesh Sanjeev ; Microtron Centre, Department of Studies in Physics, Mangalore University, Mangalagangotri, India
Nagesh N. Bhat ; Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai, India
Yerol Narayana ; Microtron Centre, Department of Studies in Physics, Mangalore University, Mangalagangotri, India

Puni tekst: engleski, pdf (206 KB) str. 77-82 preuzimanja: 456* citiraj
APA 6th Edition
Acharya, S., Sanjeev, G., Bhat, N.N. i Narayana, Y. (2010). Dose Rate Effect of Pulsed Electron Beam on Micronucleus Frequency in Human Peripheral Blood Lymphocytes. Arhiv za higijenu rada i toksikologiju, 61 (1), 77-82. https://doi.org/10.2478/10004-1254-61-2010-1982
MLA 8th Edition
Acharya, Santhosh, et al. "Dose Rate Effect of Pulsed Electron Beam on Micronucleus Frequency in Human Peripheral Blood Lymphocytes." Arhiv za higijenu rada i toksikologiju, vol. 61, br. 1, 2010, str. 77-82. https://doi.org/10.2478/10004-1254-61-2010-1982. Citirano 23.02.2019.
Chicago 17th Edition
Acharya, Santhosh, Ganesh Sanjeev, Nagesh N. Bhat i Yerol Narayana. "Dose Rate Effect of Pulsed Electron Beam on Micronucleus Frequency in Human Peripheral Blood Lymphocytes." Arhiv za higijenu rada i toksikologiju 61, br. 1 (2010): 77-82. https://doi.org/10.2478/10004-1254-61-2010-1982
Harvard
Acharya, S., et al. (2010). 'Dose Rate Effect of Pulsed Electron Beam on Micronucleus Frequency in Human Peripheral Blood Lymphocytes', Arhiv za higijenu rada i toksikologiju, 61(1), str. 77-82. doi: https://doi.org/10.2478/10004-1254-61-2010-1982
Vancouver
Acharya S, Sanjeev G, Bhat NN, Narayana Y. Dose Rate Effect of Pulsed Electron Beam on Micronucleus Frequency in Human Peripheral Blood Lymphocytes. Arh Hig Rada Toksikol. [Internet]. 2010 [pristupljeno 23.02.2019.];61(1):77-82. doi: https://doi.org/10.2478/10004-1254-61-2010-1982
IEEE
S. Acharya, G. Sanjeev, N.N. Bhat i Y. Narayana, "Dose Rate Effect of Pulsed Electron Beam on Micronucleus Frequency in Human Peripheral Blood Lymphocytes", Arhiv za higijenu rada i toksikologiju, vol.61, br. 1, str. 77-82, 2010. [Online]. doi: https://doi.org/10.2478/10004-1254-61-2010-1982

Sažetak
The micronucleus assay in human peripheral blood lymphocytes is a sensitive indicator of radiation damage and could serve as a biological dosimeter in evaluating suspected overexposure to ionising
radiation. Micronucleus (MN) frequency as a measure of chromosomal damage has also extensively been employed to quantify the effects of radiation dose rate on biological systems. Here we studied the effects of 8 MeV pulsed electron beam emitted by Microtron electron accelerator on MN induction at dose rates
between 35 Gy min-1 and 352.5 Gy min-1. These dose rates were achieved by varying the pulse repetition rate (PRR). Fricke dosimeter was employed to measure the absorbed dose at different PRR and to ensure uniform dose distribution of the electron beam. To study the dose rate effect, blood samples were irradiated to an absorbed dose of (4.7±0.2) Gy at different rates and cytogenetic damage was quantifi ed using the micronucleus assay. The obtained MN frequency showed no dose rate dependence within the studied dose rate range. Our earlier dose effect study using 8 MeV electrons revealed that the response of MN was linear-quadratic. Therefore, in the event of an accident, dose estimation can be made using linear-quadratic
dose response parameters, without adding dose rate as a correction factor.

Ključne riječi
dosimetry; microtron; 8 MeV electrons; pulse repetition rate

Hrčak ID: 49022

URI
https://hrcak.srce.hr/49022

[hrvatski]

Posjeta: 804 *