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Cytogenetics of Multiple Myeloma

Ružica Lasan Trčić ; Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia
Ika Kardum Skelin ; University of Zagreb, School of Medicine, Zagreb, Croatia
Dunja Šušterčić ; Laboratory for Cytology and Hematology, Department of Medicine, University Hospital »Merkur«, Zagreb, Croatia
Ana Planinc-Peraica ; University of Zagreb, School of Medicine, Zagreb, Croatia
Radmila Ajduković ; Department of Medicine, University Hospital Dubrava, Zagreb, Croatia
Višnja Hariš ; Department of Medicine, University Hospital Dubrava, Zagreb, Croatia
Rajko Kušec ; University of Zagreb, School of Medicine, Zagreb, Croatia
Davor Begović ; University of Zagreb, School of Medicine, Zagreb, Croatia

Puni tekst: engleski, pdf (86 KB) str. 41-44 preuzimanja: 1.917* citiraj
APA 6th Edition
Lasan Trčić, R., Kardum Skelin, I., Šušterčić, D., Planinc-Peraica, A., Ajduković, R., Hariš, V., ... Begović, D. (2010). Cytogenetics of Multiple Myeloma. Collegium antropologicum, 34 (1), 41-44. Preuzeto s https://hrcak.srce.hr/51239
MLA 8th Edition
Lasan Trčić, Ružica, et al. "Cytogenetics of Multiple Myeloma." Collegium antropologicum, vol. 34, br. 1, 2010, str. 41-44. https://hrcak.srce.hr/51239. Citirano 29.07.2021.
Chicago 17th Edition
Lasan Trčić, Ružica, Ika Kardum Skelin, Dunja Šušterčić, Ana Planinc-Peraica, Radmila Ajduković, Višnja Hariš, Rajko Kušec i Davor Begović. "Cytogenetics of Multiple Myeloma." Collegium antropologicum 34, br. 1 (2010): 41-44. https://hrcak.srce.hr/51239
Harvard
Lasan Trčić, R., et al. (2010). 'Cytogenetics of Multiple Myeloma', Collegium antropologicum, 34(1), str. 41-44. Preuzeto s: https://hrcak.srce.hr/51239 (Datum pristupa: 29.07.2021.)
Vancouver
Lasan Trčić R, Kardum Skelin I, Šušterčić D, Planinc-Peraica A, Ajduković R, Hariš V i sur. Cytogenetics of Multiple Myeloma. Collegium antropologicum [Internet]. 2010 [pristupljeno 29.07.2021.];34(1):41-44. Dostupno na: https://hrcak.srce.hr/51239
IEEE
R. Lasan Trčić, et al., "Cytogenetics of Multiple Myeloma", Collegium antropologicum, vol.34, br. 1, str. 41-44, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/51239. [Citirano: 29.07.2021.]

Sažetak
Great studies of multiple myeloma (MM) strongly suggested that specific chromosomal changes are of prognostic significance in patients with MM1. We have performed cytogenetic analysis and recently fluorescent in situ hybridization (FISH) on 43 cases of MM. Clonal chromosomal changes were present in 24 (56%) cases. Hyperdiploid karyotype was found in 12 (50%) cases, hypodiploid in 8 (33%) cases, and 4 (17%) cases had a pseudodiploid karyotype. The most common numerical abnormalities were gains of whole chromosomes 15, 11, 3 and 6. Whole chromosome losses were also frequent involving chromosomes X, 13, 14, and 8. Most cases showed also structural rearrangements 71% (n=17): del(1p), dup(1q), del(5q), del(13q), del(17p) and t(11;14)(q13;q32) (n=4, 17%). Chromosome –13/13q deletion was found in 42% (n=10) cases; complete loss of 13 was observed in 67% (n=7) cases, whereas 33% (n=3) had interstitial deletions. In the majority of the cases there was a mixture of abnormal and normal metaphases.

Ključne riječi
bone marrow; multiple myeloma; cytogenetics; DMSO

Hrčak ID: 51239

URI
https://hrcak.srce.hr/51239

Posjeta: 2.217 *