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The Accuracy of Fine Needle Aspiration Cytology and Flow Cytometry in Evaluation of Nodal and Extranodal Sites in Patients with Suspicion of Lymphoma

Petar Šenjug ; University of Zagreb, School of Medicine, Zagreb, Croatia
Karmen Trutin Ostović ; University of Applied Health Studies, Zagreb, Croatia
Zorana Miletić ; University of Applied Health Studies, Zagreb, Croatia
Čedna Tomasović Lončarić ; Department of Clinical and Experimental Pathology, University Hospital Dubrava, Zagreb, Croatia
Tajana Štoos-Veić ; Department of Clinical Cytology and Cytometry, University Hospital Dubrava, Zagreb, Croatia
Branimir Gizdić ; Clinic of Internal Medicine, Department of Hematology, University Hospital Dubrava, Zagreb, Croatia
Gordana Kaić ; Department of Clinical Cytology and Cytometry, University Hospital Dubrava, Zagreb, Croatia
Gorana Aralica ; Department of Clinical and Experimental Pathology, University Hospital Dubrava, Zagreb, Croatia
Vlatko Pejša ; Clinic of Internal Medicine, Department of Hematology, University Hospital Dubrava, Zagreb, Croatia
Ozren Jakšić ; Clinic of Internal Medicine, Department of Hematology, University Hospital Dubrava, Zagreb, Croatia

Puni tekst: engleski, pdf (79 KB) str. 131-137 preuzimanja: 804* citiraj
APA 6th Edition
Šenjug, P., Trutin Ostović, K., Miletić, Z., Tomasović Lončarić, Č., Štoos-Veić, T., Gizdić, B., ... Jakšić, O. (2010). The Accuracy of Fine Needle Aspiration Cytology and Flow Cytometry in Evaluation of Nodal and Extranodal Sites in Patients with Suspicion of Lymphoma. Collegium antropologicum, 34 (1), 131-137. Preuzeto s https://hrcak.srce.hr/51253
MLA 8th Edition
Šenjug, Petar, et al. "The Accuracy of Fine Needle Aspiration Cytology and Flow Cytometry in Evaluation of Nodal and Extranodal Sites in Patients with Suspicion of Lymphoma." Collegium antropologicum, vol. 34, br. 1, 2010, str. 131-137. https://hrcak.srce.hr/51253. Citirano 19.11.2019.
Chicago 17th Edition
Šenjug, Petar, Karmen Trutin Ostović, Zorana Miletić, Čedna Tomasović Lončarić, Tajana Štoos-Veić, Branimir Gizdić, Gordana Kaić, Gorana Aralica, Vlatko Pejša i Ozren Jakšić. "The Accuracy of Fine Needle Aspiration Cytology and Flow Cytometry in Evaluation of Nodal and Extranodal Sites in Patients with Suspicion of Lymphoma." Collegium antropologicum 34, br. 1 (2010): 131-137. https://hrcak.srce.hr/51253
Harvard
Šenjug, P., et al. (2010). 'The Accuracy of Fine Needle Aspiration Cytology and Flow Cytometry in Evaluation of Nodal and Extranodal Sites in Patients with Suspicion of Lymphoma', Collegium antropologicum, 34(1), str. 131-137. Preuzeto s: https://hrcak.srce.hr/51253 (Datum pristupa: 19.11.2019.)
Vancouver
Šenjug P, Trutin Ostović K, Miletić Z, Tomasović Lončarić Č, Štoos-Veić T, Gizdić B i sur. The Accuracy of Fine Needle Aspiration Cytology and Flow Cytometry in Evaluation of Nodal and Extranodal Sites in Patients with Suspicion of Lymphoma. Collegium antropologicum [Internet]. 2010 [pristupljeno 19.11.2019.];34(1):131-137. Dostupno na: https://hrcak.srce.hr/51253
IEEE
P. Šenjug, et al., "The Accuracy of Fine Needle Aspiration Cytology and Flow Cytometry in Evaluation of Nodal and Extranodal Sites in Patients with Suspicion of Lymphoma", Collegium antropologicum, vol.34, br. 1, str. 131-137, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/51253. [Citirano: 19.11.2019.]

Sažetak
Today lymphomas are defined according to a combination of morphology, immunophenotype, genetic features and clinical presentation, so beside the pure cytomorphologic analysis in diagnosis of lymphoma ancillary techniques such as cytochemistry, immunocytochemistry, molecular diagnosis and flow cytometry (FC) are often used. Our goal was to determinate how is information given by fine-needle aspiration cytology (FNAC) and FC correlated with pathohistologic diagnosis and to evaluate ability to diagnose and subclassify malignant lymphomas by FNAC and FC. This study is a retrospective chart review of patients with suspicion of lymphoma processed at University Hospital Dubrava in Zagreb. After analysis 50 patients fulfilled inclusion criteria for this study (FNAC diagnosis with or without FC and consecutive confirmatory pathohistological diagnosis). When analyzing accuracy of FNAC according to suspicion of lymphoma or NHL and differential diagnosis lymphoma sensitivity was 97.7%, specificity 85.7% and the diagnostic accuracy was 96%. When analyzing accuracy of FNAC according to the subclassification of lymphoma, sensitivity was 74.4%, specificity 85.7% and the diagnostic accuracy 76%. Combined FNAC and FC improved sensitivity, positive predictive value, negative predictive value and diagnostic accuracy. Sensitivity was 79.1% and the diagnostic accuracy 80%. We have shown that these methods can distinguish benign lymphadenopaties from lymphomas and also subclassify lymphomas and quickly provide clinicians with that information.

Ključne riječi
lymphoma; fine-needle biopsy; cytology; flow cytometry

Hrčak ID: 51253

URI
https://hrcak.srce.hr/51253

Posjeta: 1.086 *