Izvorni znanstveni članak
Detection of Human Papillomaviruses Type 16, 18 and 33 in Bronchial Aspirates of Lung Carcinoma Patients by Polymerase Chain Reaction: A Study of 84 Cases in Croatia
Božica Vrabec Branica
; Department of Cytology, University Hospital for Lung Diseases »Jordanovac«, Zagreb, Croatia
Silvana Smojver-Ježek
; Department of Cytology, University Hospital for Lung Diseases »Jordanovac«, Zagreb, Croatia
Zrinka Juroš
; Department of Cytology, University Hospital for Lung Diseases »Jordanovac«, Zagreb, Croatia
Sandra Grgić
; Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia
Nives Srpak
; Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia
Dinko Mitrečić
; Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia
Srećko Gajović
; Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia
Sažetak
Besides its well-known role in cervical carcinoma, HPV is also suggested to be involved in lung cancer development. A number of authors have been investigating the presence of HPV in histological materials. We used routine bronchial aspirates from 84 patients with lung carcinoma for DNA extraction and then performed polymerase chain reaction for high-risk HPV types 16, 18 and 33. The results were compared to those obtained from buccal and eyelid mucosa. Only three patients were positive for HPV in bronchial aspirates: one for HPV 16 type, one for HPV 18 type, and one for HPV 33. Our data indicated the low prevalence of HPV in patients with lung carcinomas in Croatia, therefore it seems unlikely that HPV contributes to the development of lung carcinomas in this region.
Ključne riječi
lung carcinoma; human papilloma virus; polymerase chain reaction
Hrčak ID:
51257
URI
Datum izdavanja:
10.3.2010.
Posjeta: 1.039 *