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The Role of Apoptosis in the Pathogenesis of Malignant Melanoma

Liborija Lugović Mihić ; Department of Dermatology and Venereology, University Hospital »Sestre Milosrdnice«, Zagreb, Croatia
Vedrana Bulat ; Department of Dermatology and Venereology, University Hospital »Sestre Milosrdnice«, Zagreb, Croatia
Mirna Šitum ; Department of Dermatology and Venereology, University Hospital »Sestre Milosrdnice«, Zagreb, Croatia
Iva Krolo ; Department of Dermatology and Venereology, University Hospital »Sestre Milosrdnice«, Zagreb, Croatia
Ana Šešerko ; Department of Dermatology and Venereology, University Hospital »Sestre Milosrdnice«, Zagreb, Croatia

Puni tekst: engleski, pdf (57 KB) str. 303-306 preuzimanja: 354* citiraj
APA 6th Edition
Lugović Mihić, L., Bulat, V., Šitum, M., Krolo, I. i Šešerko, A. (2010). The Role of Apoptosis in the Pathogenesis of Malignant Melanoma. Collegium antropologicum, 34 supplement 2 (2), 303-306. Preuzeto s https://hrcak.srce.hr/51681
MLA 8th Edition
Lugović Mihić, Liborija, et al. "The Role of Apoptosis in the Pathogenesis of Malignant Melanoma." Collegium antropologicum, vol. 34 supplement 2, br. 2, 2010, str. 303-306. https://hrcak.srce.hr/51681. Citirano 15.06.2021.
Chicago 17th Edition
Lugović Mihić, Liborija, Vedrana Bulat, Mirna Šitum, Iva Krolo i Ana Šešerko. "The Role of Apoptosis in the Pathogenesis of Malignant Melanoma." Collegium antropologicum 34 supplement 2, br. 2 (2010): 303-306. https://hrcak.srce.hr/51681
Harvard
Lugović Mihić, L., et al. (2010). 'The Role of Apoptosis in the Pathogenesis of Malignant Melanoma', Collegium antropologicum, 34 supplement 2(2), str. 303-306. Preuzeto s: https://hrcak.srce.hr/51681 (Datum pristupa: 15.06.2021.)
Vancouver
Lugović Mihić L, Bulat V, Šitum M, Krolo I, Šešerko A. The Role of Apoptosis in the Pathogenesis of Malignant Melanoma. Collegium antropologicum [Internet]. 2010 [pristupljeno 15.06.2021.];34 supplement 2(2):303-306. Dostupno na: https://hrcak.srce.hr/51681
IEEE
L. Lugović Mihić, V. Bulat, M. Šitum, I. Krolo i A. Šešerko, "The Role of Apoptosis in the Pathogenesis of Malignant Melanoma", Collegium antropologicum, vol.34 supplement 2, br. 2, str. 303-306, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/51681. [Citirano: 15.06.2021.]

Sažetak
Malignant melanoma genesis is a very complex process that involves a sequence of pathogenetic cellular events. Mutation of various genes and numerous other cellular mechanisms play an important role in the course of malignant melanocyte alteration and their malignant transformation from naevi into melanoma. Apoptosis is an active, genetically controlled process of programmed cell death, which leads to cell destruction and cell death without involvement of surrounding cells or inflammatory response. In this process, disrupted mechanisms of cell regulation and apoptosis take place in malignant melanoma cells, thus leading to their uncontrolled proliferation and melanocyte growth. Apoptosis is a process that involves two major pathways, the intrinsic and extrinsic apoptotic pathway, which interlace at certain points and ultimately result in apoptosis. It can be said that molecular events regulating cell survival, nomal growth arrest, apoptosis and cell differentiation, contribute to the overall pathogenesis of malignant cell growth. It is presumed that in the future, understanding of molecular aberrations and cellular processes, such as cell signaling, cell cycle regulation and cell apoptosis, will be essential for better patient monitoring and rational design of effective treatment.

Ključne riječi
apoptosis; melanoma; pathogenesis; caspase; oncogene

Hrčak ID: 51681

URI
https://hrcak.srce.hr/51681

Posjeta: 676 *