Stručni rad

b2-Microglobuline Plasma Level and Painful Shoulder in Haemodialysed Patients

Igor Barišić ; Department of Diagnostic and Interventional Radiology, University of Split, School of Medicine and University Hospital Split, Split, Croatia
Dragan Ljutić ; Department of Nephrology, University of Split, School of Medicine and University Hospital Split, Split, Croatia
Tonko Vlak ; Department of Physical Medicine, Rehabilitation and Rheumatology, University of Split, School of Medicine and University Hospital Split, Split, Croatia
Josip Bekavac ; Department of Orthopedics, University of Split, School of Medicine and University Hospital Split, Split, Croatia
Irena Perić ; Department of Pulmology, University of Split, School of Medicine and University Hospital Split, Split, Croatia
Kornelija Miše ; Department of Pulmology, University of Split, School of Medicine and University Hospital Split, Split, Croatia
Marisa Klančnik ; Department of Otorhinolaryngology, University of Split, School of Medicine and University Hospital Split, Split, Croatia
Stipan Janković ; Department of Diagnostic and Interventional Radiology, University of Split, School of Medicine and University Hospital Split, Split, Croatia

Sažetak

Painful shoulder in patients on chronic haemodialyis is most often associated with dialysis arthropathy or accumulation of deposits containing modified fibrils of b2- microglobuline especially in bones and joints due to insufficient elimination during the therapy. The aim of this study is to investigate whether there is connection between painful shoulder and plasma level of b2-microglobuline and to corroborate that with morphologic parameters found in proved amyloidosis. It has to be emphasized that even other causes may contribute the development of painful shoulder. Real time sonography and conventional plain radiographs of the 108 shoulders were performed in 54 patients receiving chronic haemodialysis as a treatment of terminal renal failure (without previous history of rheumatoid arthritis), 27 symptomatic with persistent pain and stiffness in both shoulders and lasting for more than 6 weeks and restriction of movements in various degree and 27 asymptomatic. Plasma level of b2-microglobuline, CRP and uric acid were taken periodically as routine procedure during a one year prospective trial, as well as plasma level of calcium, phosphor and alkaline phosphatase. Plasmatic level of b2-microglobuline is strongly connected with painful shoulder in dialyzed patients, as well as CRP as sign of acute inflammation. That is proved by morphologic parameters associated with histological proved amyloidosis in patients on long term dialysis, more then 10 years.

Ključne riječi

b2-microglobuline; painful shoulder; dialysis

Hrčak ID:

51786

URI

https://hrcak.srce.hr/51786

Datum izdavanja:

25.3.2010.

Posjeta: 1.036 *