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https://doi.org/10.2478/v10007-010-0027-6

Dizajniranje i sinteza novih derivata tiofenkarbohidrazida, tienopirazola i tienopirimidina s antioksidativnim i antitumorskim djelovanjem

AMEEN ALI ABU-HASHEM ; Photochemistry Department (Heterocyclic Unit), National Research Center, 12622 Dokki, Giza, Egypt
MOHAMED FATHY EL-SHEHRY ; Green Chemistry Department ,National Research Center, 12622 Dokki, Giza, Egypt
FARID ABD-ELRAHEEM BADRIA ; Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt

Puni tekst: engleski, pdf (104 KB) str. 311-323 preuzimanja: 1.433* citiraj
APA 6th Edition
ABU-HASHEM, A.A., EL-SHEHRY, M.F. i BADRIA, F.A. (2010). Design and synthesis of novel thiophenecarbohydrazide, thienopyrazole and thienopyrimidine derivatives as antioxidant and antitumor agents. Acta Pharmaceutica, 60 (3), 311-323. https://doi.org/10.2478/v10007-010-0027-6
MLA 8th Edition
ABU-HASHEM, AMEEN ALI, et al. "Design and synthesis of novel thiophenecarbohydrazide, thienopyrazole and thienopyrimidine derivatives as antioxidant and antitumor agents." Acta Pharmaceutica, vol. 60, br. 3, 2010, str. 311-323. https://doi.org/10.2478/v10007-010-0027-6. Citirano 18.06.2019.
Chicago 17th Edition
ABU-HASHEM, AMEEN ALI, MOHAMED FATHY EL-SHEHRY i FARID ABD-ELRAHEEM BADRIA. "Design and synthesis of novel thiophenecarbohydrazide, thienopyrazole and thienopyrimidine derivatives as antioxidant and antitumor agents." Acta Pharmaceutica 60, br. 3 (2010): 311-323. https://doi.org/10.2478/v10007-010-0027-6
Harvard
ABU-HASHEM, A.A., EL-SHEHRY, M.F., i BADRIA, F.A. (2010). 'Design and synthesis of novel thiophenecarbohydrazide, thienopyrazole and thienopyrimidine derivatives as antioxidant and antitumor agents', Acta Pharmaceutica, 60(3), str. 311-323. doi: https://doi.org/10.2478/v10007-010-0027-6
Vancouver
ABU-HASHEM AA, EL-SHEHRY MF, BADRIA FA. Design and synthesis of novel thiophenecarbohydrazide, thienopyrazole and thienopyrimidine derivatives as antioxidant and antitumor agents. Acta Pharm. [Internet]. 2010 [pristupljeno 18.06.2019.];60(3):311-323. doi: https://doi.org/10.2478/v10007-010-0027-6
IEEE
A.A. ABU-HASHEM, M.F. EL-SHEHRY i F.A. BADRIA, "Design and synthesis of novel thiophenecarbohydrazide, thienopyrazole and thienopyrimidine derivatives as antioxidant and antitumor agents", Acta Pharmaceutica, vol.60, br. 3, str. 311-323, 2010. [Online]. doi: https://doi.org/10.2478/v10007-010-0027-6

Sažetak
Etilni ester 2-amino-5-acetil-4-metil-tiofen-3-karboksilne kiseline (1) i 5-acetil-2-amino-4-metiltiofen-3-karbohidrazid (2) sintetizirani su i upotrebljeni kao reaktanti u sintezi novih spojeva 1-(5-amino-4-(3,5-dimetil-1H-pirazol-1-karbonil)-3-metiltiofen-2-il) etanona (3a), 1-(5-amino-4-(4-klor-3,5-dimetil-1H-pirazol-1-karbonil)-3-metiltiofen-2-il) etanona (3b), 1-(4-metil-2-amino-5-acetiltiofen-3-karbonil) pirazolidin-3,5-diona (4), (Z)-N'-(4-metil-2-amino-5-acetiltiofen-3-karbonil) formohidrazonske kiseline (5a), (Z)-etil-N'-(4-metil-2-amino-5-acetiltiofen-3-karbonilformo hidrazonata (5b), 6-acetil-3-amino-2,5-dimetiltieno2,3-dpirimidin-4(3H)-one (8), 5-metil-3-amino-2-merkapto-6-acetiltieno2,3-dpirimidin-4(3H)-ona (10) i 5-metil-6-acetil-2-tiokso-2,3-dihidrotieno2,3-dpirimidin-4(1H)-ona (12) kao potencijalnih antioksidansa i citostatika. Farmakološka ispitivanja ukazuju na to da spojevi 6a, 6b, 8, 10 i 12 imaju značajno antitumorsko i antioksidativno djelovanje.

Ključne riječi
tienopirazol; tieno[2,3-d]pirimidini; tiofenkarbohidrazid; antioksidativno djelovanje; bleomicin-ovisno DNA oštećenje; antitumorsko djelovanje

Hrčak ID: 53497

URI
https://hrcak.srce.hr/53497

[engleski]

Posjeta: 1.654 *