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Recurrent Chromosomal Abnormalities in Lymphomas in Fine Needle Aspirates of Lymph Node

Ružica Lasan Trčić
Dunja Šusterčić
Maja Kuspilić
Biljana Jelić-Pupškarić
Iris Fabijanić
Ika Kardum-Skelin

Puni tekst: engleski, pdf (72 KB) str. 387-393 preuzimanja: 318* citiraj
APA 6th Edition
Lasan Trčić, R., Šusterčić, D., Kuspilić, M., Jelić-Pupškarić, B., Fabijanić, I. i Kardum-Skelin, I. (2010). Recurrent Chromosomal Abnormalities in Lymphomas in Fine Needle Aspirates of Lymph Node. Collegium antropologicum, 34 (2), 387-393. Preuzeto s https://hrcak.srce.hr/56438
MLA 8th Edition
Lasan Trčić, Ružica, et al. "Recurrent Chromosomal Abnormalities in Lymphomas in Fine Needle Aspirates of Lymph Node." Collegium antropologicum, vol. 34, br. 2, 2010, str. 387-393. https://hrcak.srce.hr/56438. Citirano 16.11.2019.
Chicago 17th Edition
Lasan Trčić, Ružica, Dunja Šusterčić, Maja Kuspilić, Biljana Jelić-Pupškarić, Iris Fabijanić i Ika Kardum-Skelin. "Recurrent Chromosomal Abnormalities in Lymphomas in Fine Needle Aspirates of Lymph Node." Collegium antropologicum 34, br. 2 (2010): 387-393. https://hrcak.srce.hr/56438
Harvard
Lasan Trčić, R., et al. (2010). 'Recurrent Chromosomal Abnormalities in Lymphomas in Fine Needle Aspirates of Lymph Node', Collegium antropologicum, 34(2), str. 387-393. Preuzeto s: https://hrcak.srce.hr/56438 (Datum pristupa: 16.11.2019.)
Vancouver
Lasan Trčić R, Šusterčić D, Kuspilić M, Jelić-Pupškarić B, Fabijanić I, Kardum-Skelin I. Recurrent Chromosomal Abnormalities in Lymphomas in Fine Needle Aspirates of Lymph Node. Collegium antropologicum [Internet]. 2010 [pristupljeno 16.11.2019.];34(2):387-393. Dostupno na: https://hrcak.srce.hr/56438
IEEE
R. Lasan Trčić, D. Šusterčić, M. Kuspilić, B. Jelić-Pupškarić, I. Fabijanić i I. Kardum-Skelin, "Recurrent Chromosomal Abnormalities in Lymphomas in Fine Needle Aspirates of Lymph Node", Collegium antropologicum, vol.34, br. 2, str. 387-393, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/56438. [Citirano: 16.11.2019.]

Sažetak
The detection of specific chromosomal abnormalities is important in the diagnostic workup of aggressive lymphomas, giving its impact on the treatment strategies and prognosis. This has been accomplished by using the fluorescent in situ hybridisation method (FISH) performed on fine needle aspiration (FNA) specimens what is attractive in the diagnosis of lymphoma in the comparation with other methods for collecting samples. The cytogenetic analyses were performed in series of 80 patients with lymphoma (43 women and 37 men, median age 48, range 3–90 years). In our series 89.0% (71) of the specimens yield sufficient numbers of analysable metaphases, comprising 63 non-Hodgkin lymphomas (NHL) and 8 examples of Hodgkin disease (HD). Among 71 successful karyotyped specimens 58 (82.0%) showed clonal karyotypic abnormalities. Numerical changes in 4, structural changes in 20 and both and numerical with structural changes in 30 of 54 NHL cases. Trisomies 3, 7, 8, 12, 18, X and monosomies 1 were most common numerical abnormalities. The NHL cases were typically characterised by structural rather than numerical aberrations with chromosome arms 1p/q, 3p/q, 6q, 11q, 17p and 14q most frequently involved. The expected translocation (14;18)(q32;q21) in 8 and t(8;14)(q24;q34) in 6 cases, both translocations at the same time in three cases, complex rearrangement with chromosome 8, 14, and 18, namely t(8;14;18)(q24;q32;q21) in one case, t(11;14)(q13;q32) in three and one case with translocation 14q32 with chromosome 3q27, 6q and 14q32 were found. In 28 of 54 (52%) NHL cases t(14;v) was present. Four abnormal clones detected in Hodgkin disease were typically consisted of a small percentage of metaphases. The use of FISH method enable the detection of loss or gain of genetic material and reveal rearrangements unsuspected by conventional cytogenetics in 34 (48.0%) cases.

Ključne riječi
fine needle aspirate; lymphoma; cytogenetics

Hrčak ID: 56438

URI
https://hrcak.srce.hr/56438

Posjeta: 574 *