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Klinefelter Syndrome and Acute Basophilic Leukaemia – Case Report

Dubraka Ljubić
Nada Lang
Ika Kardum Skelin
Ružica Lasan
Mara Dominis
Leila Perković
Dubraka Županić-Krmek
Anita Grgurević-Batinica

Puni tekst: engleski, pdf (106 KB) str. 657-660 preuzimanja: 307* citiraj
APA 6th Edition
Ljubić, D., Lang, N., Kardum Skelin, I., Lasan, R., Dominis, M., Perković, L., ... Grgurević-Batinica, A. (2010). Klinefelter Syndrome and Acute Basophilic Leukaemia – Case Report. Collegium antropologicum, 34 (2), 657-660. Preuzeto s https://hrcak.srce.hr/56512
MLA 8th Edition
Ljubić, Dubraka, et al. "Klinefelter Syndrome and Acute Basophilic Leukaemia – Case Report." Collegium antropologicum, vol. 34, br. 2, 2010, str. 657-660. https://hrcak.srce.hr/56512. Citirano 17.11.2019.
Chicago 17th Edition
Ljubić, Dubraka, Nada Lang, Ika Kardum Skelin, Ružica Lasan, Mara Dominis, Leila Perković, Dubraka Županić-Krmek i Anita Grgurević-Batinica. "Klinefelter Syndrome and Acute Basophilic Leukaemia – Case Report." Collegium antropologicum 34, br. 2 (2010): 657-660. https://hrcak.srce.hr/56512
Harvard
Ljubić, D., et al. (2010). 'Klinefelter Syndrome and Acute Basophilic Leukaemia – Case Report', Collegium antropologicum, 34(2), str. 657-660. Preuzeto s: https://hrcak.srce.hr/56512 (Datum pristupa: 17.11.2019.)
Vancouver
Ljubić D, Lang N, Kardum Skelin I, Lasan R, Dominis M, Perković L i sur. Klinefelter Syndrome and Acute Basophilic Leukaemia – Case Report. Collegium antropologicum [Internet]. 2010 [pristupljeno 17.11.2019.];34(2):657-660. Dostupno na: https://hrcak.srce.hr/56512
IEEE
D. Ljubić, et al., "Klinefelter Syndrome and Acute Basophilic Leukaemia – Case Report", Collegium antropologicum, vol.34, br. 2, str. 657-660, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/56512. [Citirano: 17.11.2019.]

Sažetak
Patients with 47, XXY karyotype (Klinefelter syndrome) appear to have increased risk of developing cancer, especially male breast cancer, germ cell tumours and non Hodgkin lymphomas, but rarely acute myeloid leukaemia. We report a patient with acute basophilic leukaemia with 47, XXY karyotype in both the tumour and constitutional cells. Acute basophilic leukaemia is very rare disease comprising less than 1% of all acute myieloid leukaemias. Morphological characteristic of leukaemic blast cells is moderately basophilic cytoplasm containing a variable number of coarse basophilic granules. The most characteristic cytochemical reaction is metachromatic positivity with toluidine blue. Blast are myeloperoxidase negative. Also leukemic blasts express myeloid and monocyte markers. There is no consistent chromosomal abnormality identified in this leukaemia. This is the first reported case of acute basophilic leukaemia in patient with Klinefelter syndrome. In this article the medical history of the patient is given and the possible connection between Klinefeter syndrome and acute myeloid leukaemia is discussed.

Ključne riječi
Klinefelter syndrome; acute myeloid leukaemia; acute basophilic leukaemia

Hrčak ID: 56512

URI
https://hrcak.srce.hr/56512

Posjeta: 507 *