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Pregledni rad
https://doi.org/10.2478/10004-1254-61-2010-2021

Cadmium and Selenium Interaction in Mammals

Maja Lazarus   ORCID icon orcid.org/0000-0002-0389-9029 ; Institut za medicinska istraživanja i medicinu rada, Zagreb, Hrvatska

Puni tekst: hrvatski, pdf (115 KB) str. 357-368 preuzimanja: 600* citiraj
APA 6th Edition
Lazarus, M. (2010). Međudjelovanje kadmija i selenija u sisavaca. Arhiv za higijenu rada i toksikologiju, 61 (3), 357-368. https://doi.org/10.2478/10004-1254-61-2010-2021
MLA 8th Edition
Lazarus, Maja. "Međudjelovanje kadmija i selenija u sisavaca." Arhiv za higijenu rada i toksikologiju, vol. 61, br. 3, 2010, str. 357-368. https://doi.org/10.2478/10004-1254-61-2010-2021. Citirano 06.03.2021.
Chicago 17th Edition
Lazarus, Maja. "Međudjelovanje kadmija i selenija u sisavaca." Arhiv za higijenu rada i toksikologiju 61, br. 3 (2010): 357-368. https://doi.org/10.2478/10004-1254-61-2010-2021
Harvard
Lazarus, M. (2010). 'Međudjelovanje kadmija i selenija u sisavaca', Arhiv za higijenu rada i toksikologiju, 61(3), str. 357-368. https://doi.org/10.2478/10004-1254-61-2010-2021
Vancouver
Lazarus M. Međudjelovanje kadmija i selenija u sisavaca. Arh Hig Rada Toksikol. [Internet]. 2010 [pristupljeno 06.03.2021.];61(3):357-368. https://doi.org/10.2478/10004-1254-61-2010-2021
IEEE
M. Lazarus, "Međudjelovanje kadmija i selenija u sisavaca", Arhiv za higijenu rada i toksikologiju, vol.61, br. 3, str. 357-368, 2010. [Online]. https://doi.org/10.2478/10004-1254-61-2010-2021

Sažetak
Cadmium occurs in the environment naturally and as a pollutant. Its exposure is inevitable and may produce toxic effects in many organs and organ systems through binding to biological structures, accumulation in internal organs or induction of free radical production. Another important aspect of Cd toxicity is its interaction, often anthagonistic, with essential elements. Vice versa, additional intake of the essential elements may have beneficial influence on distribution and toxic effects of cadmium. Selenium is an essential microelement and a constituent of many selenoproteins with antioxidant properties that bind cadmium (and other toxic elements such as mercury or arsenic). This review summarizes results, to date, of cadmium toxicokinetics and toxicodinamics, selenium biokinetics and biodinamics, as well as mechanisms of cadmium-selenium interaction and their impact on the oxidative status derived from the studies based upon mainly on animal experiments and on limited number of human studies. The wide variety of different doses, dose ratios, element administration modes and exposure lenghts of cadmium and selenium often yielded contradictory results. Future studies should be focused on assessment of effects of cadmium and selenium interaction in sensitive population groups and mechanisms of that interaction. Regarding animal studies, doses and exposure should be adjusted to long-term low exposure levels that are usually found in human population.

Ključne riječi
antioxidative enzymes; cadmium toxicodinamics; cadmium toxicokinetics; lipid peroxidation; selenium biodinamics; selenium biokinetics; selenium supplementation

Hrčak ID: 58447

URI
https://hrcak.srce.hr/58447

[hrvatski]

Posjeta: 1.029 *