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Pregledni rad
https://doi.org/10.2478/10004-1254-61-2010-2032

Relationship Between Osteonecrosis of the Jaw and Bisphosphonate Treatment

Tomislav Badel   ORCID icon orcid.org/0000-0001-5872-1132 ; Zavod za stomatološku protetiku, Stomatološki fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska
Jadranka Keros ; Zavod za dentalnu antropologiju, Stomatološki fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska
Ladislav Krapac ; Poliklinika za reumatske bolesti, fi zikalnu medicinu i rehabilitaciju “dr. Drago Čop”, Zagreb, Hrvatska
Ivana Savić Pavičin   ORCID icon orcid.org/0000-0002-5210-1765 ; Zavod za dentalnu antropologiju, Stomatološki fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska

Puni tekst: hrvatski, pdf (91 KB) str. 371-379 preuzimanja: 2.638* citiraj
APA 6th Edition
Badel, T., Keros, J., Krapac, L. i Savić Pavičin, I. (2010). Povezanost osteonekroze čeljusti i terapije bisfosfonatima. Arhiv za higijenu rada i toksikologiju, 61 (3), 371-379. https://doi.org/10.2478/10004-1254-61-2010-2032
MLA 8th Edition
Badel, Tomislav, et al. "Povezanost osteonekroze čeljusti i terapije bisfosfonatima." Arhiv za higijenu rada i toksikologiju, vol. 61, br. 3, 2010, str. 371-379. https://doi.org/10.2478/10004-1254-61-2010-2032. Citirano 27.11.2021.
Chicago 17th Edition
Badel, Tomislav, Jadranka Keros, Ladislav Krapac i Ivana Savić Pavičin. "Povezanost osteonekroze čeljusti i terapije bisfosfonatima." Arhiv za higijenu rada i toksikologiju 61, br. 3 (2010): 371-379. https://doi.org/10.2478/10004-1254-61-2010-2032
Harvard
Badel, T., et al. (2010). 'Povezanost osteonekroze čeljusti i terapije bisfosfonatima', Arhiv za higijenu rada i toksikologiju, 61(3), str. 371-379. https://doi.org/10.2478/10004-1254-61-2010-2032
Vancouver
Badel T, Keros J, Krapac L, Savić Pavičin I. Povezanost osteonekroze čeljusti i terapije bisfosfonatima. Arh Hig Rada Toksikol. [Internet]. 2010 [pristupljeno 27.11.2021.];61(3):371-379. https://doi.org/10.2478/10004-1254-61-2010-2032
IEEE
T. Badel, J. Keros, L. Krapac i I. Savić Pavičin, "Povezanost osteonekroze čeljusti i terapije bisfosfonatima", Arhiv za higijenu rada i toksikologiju, vol.61, br. 3, str. 371-379, 2010. [Online]. https://doi.org/10.2478/10004-1254-61-2010-2032

Sažetak
Bisphosphonate treatment and its aetiopathogenic association with aseptic osteonecrosis of the jaw is one of the more prominent public health issues today. The aim of this review is to see into the mechanisms of bisphosphonate effects on bones described in literature (anti-osteoclastic activity, cytotoxicity, antiangiogenesis, genetic factors, and imbalance between osteoclasts and osteoblasts). Bisphosphonate treatment is the dominant cause of jaw necrosis. Epidemiological data show an exclusive incidence of osteonecrosis of the jaw in patients who took one or a combination of nitrogen-containing bisphosphonates. Risk factors vary by the bisphosphonate potency (particularly risky are the highly potent pamidronate and zoledronate, which are given intravenously), dosage, duration of treatment, and the illness. Jaw necrosis is most common in oncology patients, and only 5 % in patients with osteoporosis. From a dental-medical point of view, a good oral health is important because osteonecrosis often appears after a periodontal or oral surgical procedure.

Ključne riječi
bisphosphonates; mandible; maxilla; oral health; osteoclasts; osteoporosis

Hrčak ID: 58448

URI
https://hrcak.srce.hr/58448

[hrvatski]

Posjeta: 3.139 *