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Differential Pulse Polarographic Studies of Risperidone in Pharmaceutical Formulations

Christine Jeyaseelan
Ravin Jugade
Arun P. Joshi

Sažetak

A simple and rapid differential pulse polarographic method has been developed for trace determination of risperidone. A well-defined single peak with Ep value of –1.54 V is obtained in Britton-Robinson buffer (pH = 8.0). The linearity is valid up to 5 ´ 10–5 mol/L (r = 0.9995) with minimum detection limit of 2 ´ 10–7 mol/L. Precision of the method developed is implied from the values of the relative mean deviation, standard deviation and coefficient of variation, which are 2.4 %, 0.016 % and 3.2 %, respectively. Commercial formulations of risperidone were analyzed by calibration and standard addition methods. Recovery experiments were found to be quantitative and the determined mass per tablet was obtained within ± 0.2 % of the expected value. The studies have shown that the method is simple, reproducible and accurate and can be used in the analysis of commercial formulations.

Ključne riječi

differential pulse polarography; risperidone

Hrčak ID:

5760

URI

https://hrcak.srce.hr/5760

Datum izdavanja:

13.12.2006.

Posjeta: 1.997 *