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https://doi.org/10.2478/v10007-010-0035-6

Novi analitički pristup sa smanjenom potrošnjom organskih otapala u spektrofotometrijskoj analizi temeljenoj na prijenosu naboja: Primjena u analizi nekih antihipertenziva

IBRAHIM A. DARWISH ; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
ASHRAF M. MAHMOUD ; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
ABDUL-RAHMAN A. AL-MAJED ; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia

Fulltext: english, pdf (73 KB) pages 493-501 downloads: 240* cite
APA 6th Edition
DARWISH, I.A., MAHMOUD, A.M. & AL-MAJED, A.A. (2010). A novel analytical approach for reducing the consumption of organic solvents in the charge transfer-based spectrophotometric analysis: Application in the analysis of certain antihypertensive drugs. Acta Pharmaceutica, 60 (4), 493-501. https://doi.org/10.2478/v10007-010-0035-6
MLA 8th Edition
DARWISH, IBRAHIM A., et al. "A novel analytical approach for reducing the consumption of organic solvents in the charge transfer-based spectrophotometric analysis: Application in the analysis of certain antihypertensive drugs." Acta Pharmaceutica, vol. 60, no. 4, 2010, pp. 493-501. https://doi.org/10.2478/v10007-010-0035-6. Accessed 20 Jun. 2019.
Chicago 17th Edition
DARWISH, IBRAHIM A., ASHRAF M. MAHMOUD and ABDUL-RAHMAN A. AL-MAJED. "A novel analytical approach for reducing the consumption of organic solvents in the charge transfer-based spectrophotometric analysis: Application in the analysis of certain antihypertensive drugs." Acta Pharmaceutica 60, no. 4 (2010): 493-501. https://doi.org/10.2478/v10007-010-0035-6
Harvard
DARWISH, I.A., MAHMOUD, A.M., and AL-MAJED, A.A. (2010). 'A novel analytical approach for reducing the consumption of organic solvents in the charge transfer-based spectrophotometric analysis: Application in the analysis of certain antihypertensive drugs', Acta Pharmaceutica, 60(4), pp. 493-501. doi: https://doi.org/10.2478/v10007-010-0035-6
Vancouver
DARWISH IA, MAHMOUD AM, AL-MAJED AA. A novel analytical approach for reducing the consumption of organic solvents in the charge transfer-based spectrophotometric analysis: Application in the analysis of certain antihypertensive drugs. Acta Pharm. [Internet]. 2010 [cited 2019 June 20];60(4):493-501. doi: https://doi.org/10.2478/v10007-010-0035-6
IEEE
I.A. DARWISH, A.M. MAHMOUD and A.A. AL-MAJED, "A novel analytical approach for reducing the consumption of organic solvents in the charge transfer-based spectrophotometric analysis: Application in the analysis of certain antihypertensive drugs", Acta Pharmaceutica, vol.60, no. 4, pp. 493-501, 2010. [Online]. doi: https://doi.org/10.2478/v10007-010-0035-6

Abstracts
U radu je opisan razvoj novog analitičkog pristupa koji 50 puta smanjuje potrošnju organskih otapala u spektrofotometrijskoj analizi na bazi prijenosa naboja (CT). Predložena metoda koristi ploče s 96 jažica za izvođenje analize. CT reakcije između elektron-donora i elektron-akceptora izvodi se u jažicama s 200-µL organskog otapala. Promjene boje mjere se pomoću posebnog mikročitača za ploče s jažicama. Određeni su optimalni uvjeti za dva antihipertenzivna lijeka, ramipril (RML) i lizinopril (LSL) koji su upotrebljeni kao modelni spojevi za elektron-donorske analite, i 2,3-diklor-5,6-dicijano-1,4-benzokinon (DDQ) kao -elektronski akceptor. U optimalnim uvjetima Beerov zakon je vrijedio u koncentracijskom području 6–100 i 6–60 g mL1 za RML, odnosno LSL. Granice detekcije bile su 0,97 i 1,1 g mL1 za RML, odnosno LSL. Preciznost metode bila je zadovoljavajuća, a relativna standardna devijacija bila je manja od 1,1 %. Predložena metoda uspješno je primijenjena za analizu doziranih farmaceutskih pripravaka koji sadrže ispitivane lijekove, uz dobru točnost i preciznost. Rezultati predložene metode usporedivi su s rezultatima poznatih metoda. Postupak opisan u ovom radu vrlo je praktičan: analitičari su manje izloženi toksičnim učincima organskih otapala, troškovi analize smanjeni su 50 puta, a također ju odlikuje visoka propusnost. Iako je postupak validiran za RML i LSL, ista metoda može se upotrijebiti za elektron-donirajući analit koji ulazi u CT reakciju.

Keywords
reakcija prijenosa naboja; organsko otapalo; spektrofotometrija; ramipril; lizinopril

Hrčak ID: 59303

URI
https://hrcak.srce.hr/59303

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