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Determination of the Lipophilicity of Some New Derivatives of Thiosemicarbazide and 1,2,4-triazoline-5-thione with Potential Antituberculosis Activity

Monika Pitucha ; Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, Staszica 6, 20-081 Lublin, Poland
Beata Polak ; Department of Physical Chemistry, Chair of Chemistry, Faculty of Pharmacy, Medical University of Lublin, Staszica 6, 20-081 Lublin, Poland
Marta Swatko-Ossor ; Department of Biochemistry, Faculty of Pharmacy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland
Łukasz Popiołek ; Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, Staszica 6, 20-081 Lublin, Poland
Grażyna Ginalska ; Department of Biochemistry, Faculty of Pharmacy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland

Puni tekst: engleski, pdf (2 MB) str. 299-306 preuzimanja: 1.117* citiraj
APA 6th Edition
Pitucha, M., Polak, B., Swatko-Ossor, M., Popiołek, Ł. i Ginalska, G. (2010). Determination of the Lipophilicity of Some New Derivatives of Thiosemicarbazide and 1,2,4-triazoline-5-thione with Potential Antituberculosis Activity. Croatica Chemica Acta, 83 (3), 299-306. Preuzeto s https://hrcak.srce.hr/62207
MLA 8th Edition
Pitucha, Monika, et al. "Determination of the Lipophilicity of Some New Derivatives of Thiosemicarbazide and 1,2,4-triazoline-5-thione with Potential Antituberculosis Activity." Croatica Chemica Acta, vol. 83, br. 3, 2010, str. 299-306. https://hrcak.srce.hr/62207. Citirano 08.03.2021.
Chicago 17th Edition
Pitucha, Monika, Beata Polak, Marta Swatko-Ossor, Łukasz Popiołek i Grażyna Ginalska. "Determination of the Lipophilicity of Some New Derivatives of Thiosemicarbazide and 1,2,4-triazoline-5-thione with Potential Antituberculosis Activity." Croatica Chemica Acta 83, br. 3 (2010): 299-306. https://hrcak.srce.hr/62207
Harvard
Pitucha, M., et al. (2010). 'Determination of the Lipophilicity of Some New Derivatives of Thiosemicarbazide and 1,2,4-triazoline-5-thione with Potential Antituberculosis Activity', Croatica Chemica Acta, 83(3), str. 299-306. Preuzeto s: https://hrcak.srce.hr/62207 (Datum pristupa: 08.03.2021.)
Vancouver
Pitucha M, Polak B, Swatko-Ossor M, Popiołek Ł, Ginalska G. Determination of the Lipophilicity of Some New Derivatives of Thiosemicarbazide and 1,2,4-triazoline-5-thione with Potential Antituberculosis Activity. Croatica Chemica Acta [Internet]. 2010 [pristupljeno 08.03.2021.];83(3):299-306. Dostupno na: https://hrcak.srce.hr/62207
IEEE
M. Pitucha, B. Polak, M. Swatko-Ossor, Ł. Popiołek i G. Ginalska, "Determination of the Lipophilicity of Some New Derivatives of Thiosemicarbazide and 1,2,4-triazoline-5-thione with Potential Antituberculosis Activity", Croatica Chemica Acta, vol.83, br. 3, str. 299-306, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/62207. [Citirano: 08.03.2021.]

Sažetak
The chromatographic behavior of newly obtained derivatives of thiosemicarbazide and 1,2,4-
triazoline-5-thione was determined. The lipophilicity was confirmed by the use of the Reversed Phase
Thin-Layer Chromatography (RP-TLC) method. For both groups of solutes the lipophilicity depended on
the substituents. All obtained compounds were tested for their antimycotic activity. The strongest antituberculosis
activity was observed for 4-(2-iodophenyl)-1-(pyridine-4-ylacetyl)thiosemicarbazide 4 and 4-
phenyl-3-(pyridine-4-ylmethyl)-1,2,4-triazoline-5-thione 27.

Ključne riječi
thiosemicarbazide; 1; 2; 4-triazoline-5-thione; Mycobacterium tuberculosis; lipophilicity

Hrčak ID: 62207

URI
https://hrcak.srce.hr/62207

Posjeta: 1.376 *