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COMBINED ULTRASOUND AND BIOCHEMICAL SCREENING FOR FETAL ANEUPLOIDY AT 10 – 14 WEEKS OF PREGNANCY: FIRST RESULTS OF TEST PERFORMANCE IN CROATIA
Dubravka Tišlarić-Medenjak
; Endokrinološki laboratorij, Klinička bolnica »Sestre milosrdnice«, Zagreb
Vesna Košec
; Klinika za ginekologiju i porodništvo, Klinička bolnica »Sestre milosrdnice«, Zagreb
Milan Kos
; Ginekološka ordinacija, Poliklinika »Vili«, Zagreb
Višnja Latin
; Ginekološka ordinacija, Poliklinika »Vili«, Zagreb
Vesna Harni
; Ginekološka ordinacija, Poliklinika »Dr. Harni«, Zagreb
Boris Lovrić
; Ginekološki odjel, Opća bolnica, Nova Gradiška
Neven Tučkar
; Klinika za ginekologiju i porodništvo, Klinička bolnica »Sestre milosrdnice«, Zagreb
Senka Sabolović-Rudman
; Klinika za ginekologiju i porodništvo, Klinička bolnica »Sestre milosrdnice«, Zagreb
Radoslav Herman
; Klinika za ginekologiju i porodništvo, Klinička bolnica »Sestre milosrdnice«, Zagreb
Mišo Končar
; Ginekološka ordinacija, Poliklinika »Dr. Bates«, Zagreb
Željko Duić
; Klinika za ginekologiju i porodništvo, Klinička bolnica »Merkur«, Zagreb
Mario Podobnik
; »Rodilište&Poliklinika Podobnik«, Zagreb
Dragana Ljubojević-Grgec
; Ginekološka ordinacija, Poliklinika »Ginoderma«, Zagreb
Hrvojka Soljačić-Vraneš
; Klinika za ginekologiju i porodništvo, Klinička bolnica »Sestre milosrdnice«, Zagreb
Ivana Tonković-Đurišević
; Zavod za genetiku i bolesti metabolizma, Klinika za pedijatriju, KBC »Rebro«, Zagreb
Maja Gudelj
; Ginekološka ordinacija, Poliklinika »Dr. Harni«, Zagreb
Ulla Marton
; Ginekološka ordinacija, Poliklinika »Dr. Marton«, Zagreb
Milorad Lončar
; Ginekološka ordinacija »Dr. Milorad Lončar«, Karlovac
Branko Rajhvajn
; Ginekološka ordinacija »Supernova«, Zagreb
Dario Majnarić
; Ginekološka ordinacija, Poliklinika »Pronatal«, Zagreb
Tomislav Hafner
; Klinika za ginekologiju i porodništvo, Opća bolnica »Sveti Duh«, Zagreb
Zrinka Komadina-Estatiev
; Ginekološka ordinacija, Dom zdravlja, Gospić
Saša Kralik-Oguić
; Endokrinološki laboratorij, Klinika za ženske bolesti, Zagreb
Ljiljana Kovaćević
; Ginekološka ordinacija »Dr. Ljiljana Kovačević«, Zagreb
Frano Franičević
; Ginekološka ordinacija »Dr. Frano Franičević«, Zagreb
Walid El-Kawan
; Ginekološka ordinacija, Dom zdravlja, Velika Gorica
Fedora Stipoljev
; Odjek za patologiju, citologiju i citodijagnostiku, Opća bolnica »Sveti Duh«, Zagreb
Sažetak
Objective. Retrospective study of the results of the first-trimester combined screening for fetal trisomies with ultrasound and biochemical markers. Methods. In the period from February 2006 to July 2008, a total of 1112 pregnant-women underwent screening between the 10th and 14th gestational week. Individual risk for trisomies 21, 18 and 13, combining maternal age, ultrasonography (nuchal translucency, crown-rump length) and serum biochemical analytes (free -hCG, PAPP-A) was computed by means of licensed Typolog software. Concentrations of biochemical markers were determined by chemiluminiscent immunometric assay (IMMULITE). Both biochemical markers, as well as NT, were expressed as Multiples of the Median (MoM), based on the regressed medians of the corresponding gestational age in unaffected pregnancies. Results. All studied pregnancies were followed up to term. A total of 62 pregnant women were categorized as high-risk for trisomy 21, and 10 of them had also an elevated risk for trisomies 18/13, respectively. Four trisomies 21 and one trisomy 18 were detected through combined test and confirmed with prenatal diagnostic procedure. Detection rate was 100%. In those with high risk, 7 chorionic villi sampling and 38 amniocenteses were performed. False-positive rate was 5.1%. Conclusion. The results of the first-trimester screening in Croatia confirmed high sensitivity and better specificity of the combined ultrasonic and biochemical markers, in relation with the second-trimester biochemical screening test.
Ključne riječi
Syndrome Down; first-trimester screening; PAPP-A; free -hCG; nuchal translucency
Hrčak ID:
62294
URI
Datum izdavanja:
1.12.2008.
Posjeta: 5.712 *