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Spectrophotometric Determination of Isoxsuprine Hydrochloride as Base Form in Pharmaceutical Formulation through Charge Transfer Complexation

Kanakapura Basavaiah ; Department of Chemistry, University of Mysore, Manasagangothri, Mysore-570006, India
Kalsang Tharpa ; Department of Chemistry, University of Mysore, Manasagangothri, Mysore-570006, India
Kanakapura Basavaiah Vinay ; Department of Chemistry, University of Mysore, Manasagangothri, Mysore-570006, India

Puni tekst: engleski, pdf (659 KB) str. 415-420 preuzimanja: 1.406* citiraj
APA 6th Edition
Basavaiah, K., Tharpa, K. i Basavaiah Vinay, K. (2010). Spectrophotometric Determination of Isoxsuprine Hydrochloride as Base Form in Pharmaceutical Formulation through Charge Transfer Complexation. Croatica Chemica Acta, 83 (4), 415-420. Preuzeto s https://hrcak.srce.hr/62646
MLA 8th Edition
Basavaiah, Kanakapura, et al. "Spectrophotometric Determination of Isoxsuprine Hydrochloride as Base Form in Pharmaceutical Formulation through Charge Transfer Complexation." Croatica Chemica Acta, vol. 83, br. 4, 2010, str. 415-420. https://hrcak.srce.hr/62646. Citirano 08.03.2021.
Chicago 17th Edition
Basavaiah, Kanakapura, Kalsang Tharpa i Kanakapura Basavaiah Vinay. "Spectrophotometric Determination of Isoxsuprine Hydrochloride as Base Form in Pharmaceutical Formulation through Charge Transfer Complexation." Croatica Chemica Acta 83, br. 4 (2010): 415-420. https://hrcak.srce.hr/62646
Harvard
Basavaiah, K., Tharpa, K., i Basavaiah Vinay, K. (2010). 'Spectrophotometric Determination of Isoxsuprine Hydrochloride as Base Form in Pharmaceutical Formulation through Charge Transfer Complexation', Croatica Chemica Acta, 83(4), str. 415-420. Preuzeto s: https://hrcak.srce.hr/62646 (Datum pristupa: 08.03.2021.)
Vancouver
Basavaiah K, Tharpa K, Basavaiah Vinay K. Spectrophotometric Determination of Isoxsuprine Hydrochloride as Base Form in Pharmaceutical Formulation through Charge Transfer Complexation. Croatica Chemica Acta [Internet]. 2010 [pristupljeno 08.03.2021.];83(4):415-420. Dostupno na: https://hrcak.srce.hr/62646
IEEE
K. Basavaiah, K. Tharpa i K. Basavaiah Vinay, "Spectrophotometric Determination of Isoxsuprine Hydrochloride as Base Form in Pharmaceutical Formulation through Charge Transfer Complexation", Croatica Chemica Acta, vol.83, br. 4, str. 415-420, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/62646. [Citirano: 08.03.2021.]

Sažetak
Two simple and selective spectrophotometric methods are described for the determination of
isoxsuprine hydrochloride (ISX·HCl) as base form in bulk drug and in injections and tablets. The methods
are based on the molecular charge-transfer complexation of ISX base (ISX) with either p-chloranilic acid
(PCA) or 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). The intense colored radical anions formed
on dissociation, are quantitated at 520 nm (PCA method) or 600 nm (DDQ method). The optimum assay
conditions were optimized. Beer's law is obeyed in the concentration ranges 5.28 × 10–5 to 42.2 × 10–5 mol
dm–3 in PCA method and 0.79 × 10–5 to 10.6 × 10–5 mol dm–3 in DDQ method, with respective molar absorptivity
values of 1.32 × 103 and 6.55 × 103 dm3 mol–1 cm–1. The reaction stoichiometry in both methods
was evaluated by either Job’s method or limiting logarithmic method and was found to be 1:1 (ISX: PCA,
ISX: DDQ). Developed methods were validated according to ICH guidelines and found to be accurate and
precise.

Ključne riječi
isoxsuprine hydrochloride; p-chloranilic acid; 2; 3-dichloro-5; 6-dicyano-1; 4-benzoquinone; spectrophotometry; injection; tablets

Hrčak ID: 62646

URI
https://hrcak.srce.hr/62646

Posjeta: 1.668 *