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https://doi.org/10.2478/v10007-011-0004-8

Smanjenje genotoksičnosti cisplatina u neciljnim stanicama miša upotrebom gela s protransfersomima u terapiji karcinoma skvamoznih stanica kože

VANDANA GUPTA ; School of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Airport Bypass Road, Gandhi Nagar, Bhopal (MP)-462036, India
RAMESH CHANDRA Agrawal ; Jawaharlal Nehru Cancer Hospital and Research Center, Post Box. No. 32, Idgah Hills, Bhopal-462001 (MP) India
PIYUSH TRIVEDI ; School of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Airport Bypass Road, Gandhi Nagar, Bhopal (MP)-462036, India

Puni tekst: engleski, pdf (126 KB) str. 63-71 preuzimanja: 441* citiraj
APA 6th Edition
GUPTA, V., Agrawal, R.C. i TRIVEDI, P. (2011). Reduction in cisplatin genotoxicity (micronucleus formation) on non target cells in mice by protransfersome gel formulation used for management of cutaneous squamous cell carcinoma. Acta Pharmaceutica, 61 (1), 63-71. https://doi.org/10.2478/v10007-011-0004-8
MLA 8th Edition
GUPTA, VANDANA, et al. "Reduction in cisplatin genotoxicity (micronucleus formation) on non target cells in mice by protransfersome gel formulation used for management of cutaneous squamous cell carcinoma." Acta Pharmaceutica, vol. 61, br. 1, 2011, str. 63-71. https://doi.org/10.2478/v10007-011-0004-8. Citirano 19.06.2019.
Chicago 17th Edition
GUPTA, VANDANA, RAMESH CHANDRA Agrawal i PIYUSH TRIVEDI. "Reduction in cisplatin genotoxicity (micronucleus formation) on non target cells in mice by protransfersome gel formulation used for management of cutaneous squamous cell carcinoma." Acta Pharmaceutica 61, br. 1 (2011): 63-71. https://doi.org/10.2478/v10007-011-0004-8
Harvard
GUPTA, V., Agrawal, R.C., i TRIVEDI, P. (2011). 'Reduction in cisplatin genotoxicity (micronucleus formation) on non target cells in mice by protransfersome gel formulation used for management of cutaneous squamous cell carcinoma', Acta Pharmaceutica, 61(1), str. 63-71. doi: https://doi.org/10.2478/v10007-011-0004-8
Vancouver
GUPTA V, Agrawal RC, TRIVEDI P. Reduction in cisplatin genotoxicity (micronucleus formation) on non target cells in mice by protransfersome gel formulation used for management of cutaneous squamous cell carcinoma. Acta Pharm. [Internet]. 2011 [pristupljeno 19.06.2019.];61(1):63-71. doi: https://doi.org/10.2478/v10007-011-0004-8
IEEE
V. GUPTA, R.C. Agrawal i P. TRIVEDI, "Reduction in cisplatin genotoxicity (micronucleus formation) on non target cells in mice by protransfersome gel formulation used for management of cutaneous squamous cell carcinoma", Acta Pharmaceutica, vol.61, br. 1, str. 63-71, 2011. [Online]. doi: https://doi.org/10.2478/v10007-011-0004-8

Sažetak
U radu je opisana priprema protransfersoma s cisplatinom te njihova evaluacija: permeacija lijeka in vitro, odlaganje ljekovite tvari, histopatološke studije, antitumorski učinak i genotoksično djelovanje. Permeacija kroz kožu iz protransfersoma bila je 494,33 ± 11,87 μg cm–2, što je značajno više nego iz otopine lijeka u 0,9 % otopini NaCl (p < 0,001). Uz terapiju protransfersomima pojavila se obična hiperplazija epitela (prekancerozno stanje), dok su se u skupini netretiranih životinja pojavile invazivne, umjereno diferencirane skvamozne stanice karcinoma (maligno stanje). Osim toga, stvaranje stanica s malim jezgrama u skupini životinja koje su tretirane intraperitonealnim injekcijama cisplatina u fiziološkoj otopini bilo je značajnije u odnosu na skupinu koja je tretirana s topičkom formulacijom protransfersoma. Rezultati rada pokazuju da je formulacijom s protransfersomima postignuto poboljšano, specifično i lokalizirano djelovanje u koži, što pruža mogućnost boljeg rješavanja problema kao što je karcinom skvamoznih stanica.

Ključne riječi
cisplatin; protransfersom; topička kemoterapija; oštećenje gena; stanice koštane srži; polikromatski eritrociti s mikronukleusom

Hrčak ID: 63373

URI
https://hrcak.srce.hr/63373

[engleski]

Posjeta: 696 *