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https://doi.org/10.2478/v10007-011-0001-y
Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities
RAFAT M. MOHAREB
; October University for Modern Sciences and Arts, October City, A. R. Egypt
HOSAM E. MOUSTAFA
; Applied Medical Sciences Department, Community College in Quaryat, Al Jouf University, Al Jouf, Saudia Arabia
Puni tekst: engleski, pdf (97 KB)
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str. 51-62 |
preuzimanja: 512* |
citiraj |
APA 6th Edition MOHAREB, R.M. i MOUSTAFA, H.E. (2011). Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities. Acta Pharmaceutica, 61 (1), 51-62. https://doi.org/10.2478/v10007-011-0001-y
MLA 8th Edition MOHAREB, RAFAT M. i HOSAM E. MOUSTAFA. "Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities." Acta Pharmaceutica, vol. 61, br. 1, 2011, str. 51-62. https://doi.org/10.2478/v10007-011-0001-y. Citirano 18.02.2019.
Chicago 17th Edition MOHAREB, RAFAT M. i HOSAM E. MOUSTAFA. "Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities." Acta Pharmaceutica 61, br. 1 (2011): 51-62. https://doi.org/10.2478/v10007-011-0001-y
Harvard MOHAREB, R.M., i MOUSTAFA, H.E. (2011). 'Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities', Acta Pharmaceutica, 61(1), str. 51-62. doi: https://doi.org/10.2478/v10007-011-0001-y
Vancouver MOHAREB RM, MOUSTAFA HE. Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities. Acta Pharm. [Internet]. 2011 [pristupljeno 18.02.2019.];61(1):51-62. doi: https://doi.org/10.2478/v10007-011-0001-y
IEEE R.M. MOHAREB i H.E. MOUSTAFA, "Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities", Acta Pharmaceutica, vol.61, br. 1, str. 51-62, 2011. [Online]. doi: https://doi.org/10.2478/v10007-011-0001-y
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Sažetak The aim of the work was to synthesize heterocyclic compounds from 2-aminoprop-1-ene-1,1,3-tricarbonitrile and to study their antitumor activities. The title reagent reacted with cyclohexanone to give the ethylidene derivative 2. The reactivity of the latter product towards different reagents was studied to give tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives. The newly synthesized products were screened as antitumor agents on the in vitro growth of three human tumor cell lines representing different tumor types, namely, breast adenocarcinoma (MFC-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268). It was found that some of these compounds showed inhibitory effects on the three cell lines, indicating their potential use in the development of oncology products.
Ključne riječi tetrahydronaphthalene; hexahydroisoquinoline; hexahydrocinnoline; antitumor activity
Hrčak ID: 63376
URI https://hrcak.srce.hr/63376
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