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Acta Pharmaceutica, Vol. 61 No. 1, 2011.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-011-0001-y

Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities

RAFAT M. MOHAREB ; October University for Modern Sciences and Arts, October City, A. R. Egypt
HOSAM E. MOUSTAFA ; Applied Medical Sciences Department, Community College in Quaryat, Al Jouf University, Al Jouf, Saudia Arabia

Puni tekst: engleski, pdf (97 KB) str. 51-62 preuzimanja: 548* citiraj
APA 6th Edition
MOHAREB, R.M. i MOUSTAFA, H.E. (2011). Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities. Acta Pharmaceutica, 61 (1), 51-62. https://doi.org/10.2478/v10007-011-0001-y
MLA 8th Edition
MOHAREB, RAFAT M. i HOSAM E. MOUSTAFA. "Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities." Acta Pharmaceutica, vol. 61, br. 1, 2011, str. 51-62. https://doi.org/10.2478/v10007-011-0001-y. Citirano 17.06.2019.
Chicago 17th Edition
MOHAREB, RAFAT M. i HOSAM E. MOUSTAFA. "Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities." Acta Pharmaceutica 61, br. 1 (2011): 51-62. https://doi.org/10.2478/v10007-011-0001-y
Harvard
MOHAREB, R.M., i MOUSTAFA, H.E. (2011). 'Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities', Acta Pharmaceutica, 61(1), str. 51-62. doi: https://doi.org/10.2478/v10007-011-0001-y
Vancouver
MOHAREB RM, MOUSTAFA HE. Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities. Acta Pharm. [Internet]. 2011 [pristupljeno 17.06.2019.];61(1):51-62. doi: https://doi.org/10.2478/v10007-011-0001-y
IEEE
R.M. MOHAREB i H.E. MOUSTAFA, "Use of 2-aminoprop-1-ene-1,1,3-tricarbonitrile for the synthesis of tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives with potential antitumor activities", Acta Pharmaceutica, vol.61, br. 1, str. 51-62, 2011. [Online]. doi: https://doi.org/10.2478/v10007-011-0001-y

Sažetak
The aim of the work was to synthesize heterocyclic compounds from 2-aminoprop-1-ene-1,1,3-tricarbonitrile and to study their antitumor activities. The title reagent reacted with cyclohexanone to give the ethylidene derivative 2. The reactivity of the latter product towards different reagents was studied to give tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives. The newly synthesized products were screened as antitumor agents on the in vitro growth of three human tumor cell lines representing different tumor types, namely, breast adenocarcinoma (MFC-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268). It was found that some of these compounds showed inhibitory effects on the three cell lines, indicating their potential use in the development of oncology products.

Ključne riječi
tetrahydronaphthalene; hexahydroisoquinoline; hexahydrocinnoline; antitumor activity

Hrčak ID: 63376

URI
https://hrcak.srce.hr/63376

[hrvatski]

Posjeta: 736 *