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Pregledni rad
https://doi.org/10.2478/v10007-011-0006-6

Metal ions, Alzheimer’s disease and chelation therapy

ANA BUDIMIR ; University of Zagreb, Faculty of Pharmacy and Biochemistry, 10000 Zagreb, Croatia

Puni tekst: engleski, pdf (105 KB) str. 1-14 preuzimanja: 1.615* citiraj
APA 6th Edition
BUDIMIR, A. (2011). Metal ions, Alzheimer’s disease and chelation therapy. Acta Pharmaceutica, 61 (1), 1-14. https://doi.org/10.2478/v10007-011-0006-6
MLA 8th Edition
BUDIMIR, ANA. "Metal ions, Alzheimer’s disease and chelation therapy." Acta Pharmaceutica, vol. 61, br. 1, 2011, str. 1-14. https://doi.org/10.2478/v10007-011-0006-6. Citirano 19.06.2019.
Chicago 17th Edition
BUDIMIR, ANA. "Metal ions, Alzheimer’s disease and chelation therapy." Acta Pharmaceutica 61, br. 1 (2011): 1-14. https://doi.org/10.2478/v10007-011-0006-6
Harvard
BUDIMIR, A. (2011). 'Metal ions, Alzheimer’s disease and chelation therapy', Acta Pharmaceutica, 61(1), str. 1-14. doi: https://doi.org/10.2478/v10007-011-0006-6
Vancouver
BUDIMIR A. Metal ions, Alzheimer’s disease and chelation therapy. Acta Pharm. [Internet]. 2011 [pristupljeno 19.06.2019.];61(1):1-14. doi: https://doi.org/10.2478/v10007-011-0006-6
IEEE
A. BUDIMIR, "Metal ions, Alzheimer’s disease and chelation therapy", Acta Pharmaceutica, vol.61, br. 1, str. 1-14, 2011. [Online]. doi: https://doi.org/10.2478/v10007-011-0006-6

Sažetak
In the last few years, various studies have been providing evidence that metal ions are critically involved in the pathogenesis of major neurological diseases (Alzheimer, Parkinson). Metal ion chelators have been suggested as potential therapies for diseases involving metal ion imbalance. Neurodegeneration represents an excellent target for exploiting the metal chelator approach to therapeutics. In contrast to the direct chelation approach in metal ion overload disorders, in neurodegeneration the goal seems to be a better and subtle modulation of metal ion homeostasis, aimed at restoring ionic balance. Thus, moderate chelators able to coordinate deleterious metals without disturbing metal homeostasis are needed. To date, several chelating agents have been investigated for their potential to treat neurodegeneration, and a series of 8-hydroxyquinoline analogues showed the greatest potential for the treatment of neurodegenerative diseases.

Ključne riječi
metal ions; Alzheimer’s disease; neurodegeneration; metal chelators; chelation therapy

Hrčak ID: 63377

URI
https://hrcak.srce.hr/63377

[hrvatski]

Posjeta: 2.040 *