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THE ROLE OF BCL-2 FAMILY PROTEINS IN PSORIASIS

MARIJA KAŠTELAN
LARISA PRPIĆ MASSARI
INES BRAJAC

Puni tekst: hrvatski, pdf (88 KB) str. 31-33 preuzimanja: 358* citiraj
APA 6th Edition
KAŠTELAN, M., PRPIĆ MASSARI, L. i BRAJAC, I. (2010). ULOGA PROTEINA PORODICE BCL-2 U PSORIJAZI. Liječnički vjesnik, 132 (1-2), 31-33. Preuzeto s https://hrcak.srce.hr/63557
MLA 8th Edition
KAŠTELAN, MARIJA, et al. "ULOGA PROTEINA PORODICE BCL-2 U PSORIJAZI." Liječnički vjesnik, vol. 132, br. 1-2, 2010, str. 31-33. https://hrcak.srce.hr/63557. Citirano 25.01.2020.
Chicago 17th Edition
KAŠTELAN, MARIJA, LARISA PRPIĆ MASSARI i INES BRAJAC. "ULOGA PROTEINA PORODICE BCL-2 U PSORIJAZI." Liječnički vjesnik 132, br. 1-2 (2010): 31-33. https://hrcak.srce.hr/63557
Harvard
KAŠTELAN, M., PRPIĆ MASSARI, L., i BRAJAC, I. (2010). 'ULOGA PROTEINA PORODICE BCL-2 U PSORIJAZI', Liječnički vjesnik, 132(1-2), str. 31-33. Preuzeto s: https://hrcak.srce.hr/63557 (Datum pristupa: 25.01.2020.)
Vancouver
KAŠTELAN M, PRPIĆ MASSARI L, BRAJAC I. ULOGA PROTEINA PORODICE BCL-2 U PSORIJAZI. Liječnički vjesnik [Internet]. 2010 [pristupljeno 25.01.2020.];132(1-2):31-33. Dostupno na: https://hrcak.srce.hr/63557
IEEE
M. KAŠTELAN, L. PRPIĆ MASSARI i I. BRAJAC, "ULOGA PROTEINA PORODICE BCL-2 U PSORIJAZI", Liječnički vjesnik, vol.132, br. 1-2, str. 31-33, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/63557. [Citirano: 25.01.2020.]

Sažetak
Apoptosis is a physiological process of programmed cell death responsible for homeostasis in the body. In skin, apoptotic process regulates keratinocyte proliferation and differentiation in that way maintaining homeostasis of epidermal compartment. The process of apoptosis is controlled by proteins of the Bcl-2 family, several proapoptotic (Bax, Bak, Bad) and antiapoptotic (Bcl-2, Bcl-xL) proteins. Nowadays, it seems that dysfunctional apoptosis has an important role in the pathogenesis of several skin diseases. Psoriasis is a chronic hypeproliferative inflammatory skin disease characterized by abnormal keratinocyte hyperproliferation and differentiation as well as by decreased keratinocyte apoptosis. Based on recent studies, it is likely that apoptosis has an important role in epidermal hyperproliferation of psoriatic lesion. Having in mind the significance of Bcl-2 family proteins in apoptosis, it is important to elucidate their role in psoriasis pathogenesis. Observed upregulation of antiapoptotic and downregulation of proapoptotic Bcl-2 family molecules in psoriatic skin implies their significance in psoriasis development.

Ključne riječi
Psoriasis – etiology, metabolism, pathology; Keratinocytes – physiology, metabolism; Apoptosis – physiology; Proto-oncogene proteins C-Bcl-2 – physiology, metabolism

Hrčak ID: 63557

URI
https://hrcak.srce.hr/63557

[hrvatski]

Posjeta: 671 *