hrcak mascot   Srce   HID

Pregledni rad

STIFF PERSON SYNDROME (MOERSCH-WOLTMAN)

DENIS ČERIMAGIĆ
ERVINA BILIĆ

Puni tekst: hrvatski, pdf (140 KB) str. 110-114 preuzimanja: 1.375* citiraj
APA 6th Edition
ČERIMAGIĆ, D. i BILIĆ, E. (2010). SINDROM UKOČENE OSOBE (MOERSCH-WOLTMAN). Liječnički vjesnik, 132 (3-4), 110-114. Preuzeto s https://hrcak.srce.hr/63570
MLA 8th Edition
ČERIMAGIĆ, DENIS i ERVINA BILIĆ. "SINDROM UKOČENE OSOBE (MOERSCH-WOLTMAN)." Liječnički vjesnik, vol. 132, br. 3-4, 2010, str. 110-114. https://hrcak.srce.hr/63570. Citirano 12.12.2019.
Chicago 17th Edition
ČERIMAGIĆ, DENIS i ERVINA BILIĆ. "SINDROM UKOČENE OSOBE (MOERSCH-WOLTMAN)." Liječnički vjesnik 132, br. 3-4 (2010): 110-114. https://hrcak.srce.hr/63570
Harvard
ČERIMAGIĆ, D., i BILIĆ, E. (2010). 'SINDROM UKOČENE OSOBE (MOERSCH-WOLTMAN)', Liječnički vjesnik, 132(3-4), str. 110-114. Preuzeto s: https://hrcak.srce.hr/63570 (Datum pristupa: 12.12.2019.)
Vancouver
ČERIMAGIĆ D, BILIĆ E. SINDROM UKOČENE OSOBE (MOERSCH-WOLTMAN). Liječnički vjesnik [Internet]. 2010 [pristupljeno 12.12.2019.];132(3-4):110-114. Dostupno na: https://hrcak.srce.hr/63570
IEEE
D. ČERIMAGIĆ i E. BILIĆ, "SINDROM UKOČENE OSOBE (MOERSCH-WOLTMAN)", Liječnički vjesnik, vol.132, br. 3-4, str. 110-114, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/63570. [Citirano: 12.12.2019.]

Sažetak
The prime goal of this paper is to offer an overview of main scientific points in epidemiology, genetics, pathogenesis, clinical course and therapeutic strategies in stiff person syndrome (SPS). This syndrome is characterized by progressive muscle rigidity and painful muscle spasms. Three major forms of SPS are described, according to the pathophysiologic basis, autoimmune, paraneoplastic and idiopathic SPS. In autoimmune form of SPS the antibodies are specific for an enzyme (glutamic acid decarboxylase, GAD). If the paraneoplastic form takes place, the antibodies may be specific for presynaptic (amphyphysin) or the postsynaptic protein (gephyrin). The SPS diagnosis should be based on clinical, laboratory and electromyoneurographic criteria, according to Gordon and Lorish. The therapeutic approaches are focused on symptomatic therapy managing the muscle spasm and on possible immunomodulatory procedures to attenuate an autoimmune reaction. Two cases of SPS are reported in the Republic Croatia since 2005. Although it is a rare medical condition, SPS is of clinical importance, especially because it may be the first sign of an underlying undiagnosed malignant disease or if the anesthesia is necessary in SPS patient.

Ključne riječi
Stiff-person syndrome – etiology; diagnosis; therapy

Hrčak ID: 63570

URI
https://hrcak.srce.hr/63570

[hrvatski]

Posjeta: 1.926 *