Izvorni znanstveni članak
Effect of Olive Oil on Brain’s Lipid and Calcium Content after Partial Hepatectomy in Mice
Radojka Pantović
Marin Tota
Leo Štefan
Čedomila Milin
Sažetak
The aim of this study was to investigate the influence of olive oil (OO) enriched diet on the lipid content of mice brain during the early phase of liver regeneration and to test a relationship of these changes with calcium content. C57Bl mice were fed over 21 days with diet enriched with olive oil, containing predominantly oleic acid (18:1n-9). The animals were one-third partially hepatectomised (pHx) under aether anaesthesia. Total lipids were extracted from tissue samples with a chloroform-methanol (2:1, v/v) mixture according to Folch et al. Mineral concentration was determined by inductively coupled plasma atomic emission spectroscopy (ICP-AES) after microwave brain tissue digestion. The diet containing OO
increased both total lipid content and the calcium concentration in brain during the early phase of liver regeneration (12hrs post pHx), suggesting that monounsaturated oleic acid might interact with some metal-dependent activities that control changes in the brain during liver regeneration.
Ključne riječi
partial hepatectomy; diet; olive oil; total lipids; calcium; brain
Hrčak ID:
64048
URI
Datum izdavanja:
31.1.2011.
Posjeta: 1.147 *