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1-H MRS Changes in Dorsolateral Prefrontal Cortex after Donepezil Treatment in Patients with Mild to Moderate Alzheimer’s Disease

Neven Henigsberg
Petra Kalember
Pero Hrabač
Marko Radoš
Maja Bajs
Milan Radoš
Zrinka Kovačić
Mladen Lončar
Tomo Madžar

Puni tekst: engleski, pdf (127 KB) str. 159-162 preuzimanja: 267* citiraj
APA 6th Edition
Henigsberg, N., Kalember, P., Hrabač, P., Radoš, M., Bajs, M., Radoš, M., ... Madžar, T. (2011). 1-H MRS Changes in Dorsolateral Prefrontal Cortex after Donepezil Treatment in Patients with Mild to Moderate Alzheimer’s Disease. Collegium antropologicum, 35 supplement 1 (1), 159-162. Preuzeto s https://hrcak.srce.hr/64067
MLA 8th Edition
Henigsberg, Neven, et al. "1-H MRS Changes in Dorsolateral Prefrontal Cortex after Donepezil Treatment in Patients with Mild to Moderate Alzheimer’s Disease." Collegium antropologicum, vol. 35 supplement 1, br. 1, 2011, str. 159-162. https://hrcak.srce.hr/64067. Citirano 29.03.2020.
Chicago 17th Edition
Henigsberg, Neven, Petra Kalember, Pero Hrabač, Marko Radoš, Maja Bajs, Milan Radoš, Zrinka Kovačić, Mladen Lončar i Tomo Madžar. "1-H MRS Changes in Dorsolateral Prefrontal Cortex after Donepezil Treatment in Patients with Mild to Moderate Alzheimer’s Disease." Collegium antropologicum 35 supplement 1, br. 1 (2011): 159-162. https://hrcak.srce.hr/64067
Harvard
Henigsberg, N., et al. (2011). '1-H MRS Changes in Dorsolateral Prefrontal Cortex after Donepezil Treatment in Patients with Mild to Moderate Alzheimer’s Disease', Collegium antropologicum, 35 supplement 1(1), str. 159-162. Preuzeto s: https://hrcak.srce.hr/64067 (Datum pristupa: 29.03.2020.)
Vancouver
Henigsberg N, Kalember P, Hrabač P, Radoš M, Bajs M, Radoš M i sur. 1-H MRS Changes in Dorsolateral Prefrontal Cortex after Donepezil Treatment in Patients with Mild to Moderate Alzheimer’s Disease. Collegium antropologicum [Internet]. 2011 [pristupljeno 29.03.2020.];35 supplement 1(1):159-162. Dostupno na: https://hrcak.srce.hr/64067
IEEE
N. Henigsberg, et al., "1-H MRS Changes in Dorsolateral Prefrontal Cortex after Donepezil Treatment in Patients with Mild to Moderate Alzheimer’s Disease", Collegium antropologicum, vol.35 supplement 1, br. 1, str. 159-162, 2011. [Online]. Dostupno na: https://hrcak.srce.hr/64067. [Citirano: 29.03.2020.]

Sažetak
Magnetic resonance spectroscopy (MRS) noninvasively provides information on the concentration of some cerebral metabolites in vivo. Among those measurable by proton magnetic resonance spectroscopy (1H-MRS), N-acetyl-aspartate (NAA) is decreased, and myo-inositol (mI) and choline (Cho) levels are increased in patients with Alzheimer’s disease (AD). Donepezil, an acetylcholinesteraze inhibitor, has proven effect on cognitive symptoms in patients with AD. In previous studies, treatment response was associated with an increase of NAA and NAA/Cr in the parietal lobe and hippocampi. Correlation of longitudinal changes of 1H-MRS detectable metabolites in dorsolateral prefrontal cortex (DLPFC) with clinically observable changes is a poorly researched topic. The objective of this non-interventional study is to assess whether changes in 1H-MRS measurable metabolites correlate with clinical outcome after donepezil treatment. Twelve patients with mild to moderate AD were evaluated during 26 weeks of donepezil treatment. 1H-MRS parameters in DLPFC were assessed before and after 26 weeks of donepezil treatment. Cognition was assessed with Alzheimer’s Disease Assessment Scale cognitive subscale (ADAS-Cog). A significant increase in NAA/Cr ratio and significantly lower decrease
in mI/Cr ratio were found in AD patients with positive treatment response. The results of this study indicate possible modest donepezil effect on prevention of neuronal functional deterioration in DLPFC which correlates with clinical outcome and point the use of 1HMRS as technique of help in assessment of drug effect.

Ključne riječi
1H-MRS; donepezil; Alzheimer’s disease

Hrčak ID: 64067

URI
https://hrcak.srce.hr/64067

Posjeta: 527 *