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https://doi.org/10.2478/10004-1254-62-2011-2082

Antioxidative Effects of N-acetylcysteine, Lipoic Acid, Taurine, and Curcumin in the Muscle of Cyprinus carpio L. Exposed to Cadmium

Yusuf Sevgiler ; Adiyaman University, Faculty of Science and Letters, Department of Biology, Adiyaman, Turkey
Sahire Karaytug ; University of Mersin, Faculty of Aquaculture, Yenişehir Campus, Mersin, Turkey
Fahri Karayakar ; University of Mersin, Faculty of Aquaculture, Yenişehir Campus, Mersin2, Turkey

Puni tekst: engleski, pdf (139 KB) str. 1-8 preuzimanja: 706* citiraj
APA 6th Edition
Sevgiler, Y., Karaytug, S. i Karayakar, F. (2011). Antioxidative Effects of N-acetylcysteine, Lipoic Acid, Taurine, and Curcumin in the Muscle of Cyprinus carpio L. Exposed to Cadmium. Arhiv za higijenu rada i toksikologiju, 62 (1), 1-8. https://doi.org/10.2478/10004-1254-62-2011-2082
MLA 8th Edition
Sevgiler, Yusuf, et al. "Antioxidative Effects of N-acetylcysteine, Lipoic Acid, Taurine, and Curcumin in the Muscle of Cyprinus carpio L. Exposed to Cadmium." Arhiv za higijenu rada i toksikologiju, vol. 62, br. 1, 2011, str. 1-8. https://doi.org/10.2478/10004-1254-62-2011-2082. Citirano 03.03.2021.
Chicago 17th Edition
Sevgiler, Yusuf, Sahire Karaytug i Fahri Karayakar. "Antioxidative Effects of N-acetylcysteine, Lipoic Acid, Taurine, and Curcumin in the Muscle of Cyprinus carpio L. Exposed to Cadmium." Arhiv za higijenu rada i toksikologiju 62, br. 1 (2011): 1-8. https://doi.org/10.2478/10004-1254-62-2011-2082
Harvard
Sevgiler, Y., Karaytug, S., i Karayakar, F. (2011). 'Antioxidative Effects of N-acetylcysteine, Lipoic Acid, Taurine, and Curcumin in the Muscle of Cyprinus carpio L. Exposed to Cadmium', Arhiv za higijenu rada i toksikologiju, 62(1), str. 1-8. https://doi.org/10.2478/10004-1254-62-2011-2082
Vancouver
Sevgiler Y, Karaytug S, Karayakar F. Antioxidative Effects of N-acetylcysteine, Lipoic Acid, Taurine, and Curcumin in the Muscle of Cyprinus carpio L. Exposed to Cadmium. Arh Hig Rada Toksikol. [Internet]. 2011 [pristupljeno 03.03.2021.];62(1):1-8. https://doi.org/10.2478/10004-1254-62-2011-2082
IEEE
Y. Sevgiler, S. Karaytug i F. Karayakar, "Antioxidative Effects of N-acetylcysteine, Lipoic Acid, Taurine, and Curcumin in the Muscle of Cyprinus carpio L. Exposed to Cadmium", Arhiv za higijenu rada i toksikologiju, vol.62, br. 1, str. 1-8, 2011. [Online]. https://doi.org/10.2478/10004-1254-62-2011-2082

Sažetak
We investigated the muscle tissue of a teleost Cyprinus carpio L. to find out whether N-acetylcysteine (NAC), alpha-lipoic acid (LA), taurine (TAU), and curcumin (CUR) were able to counteract oxidative
stress induced by acute exposure to cadmium (Cd). The muscle tissue was dissected 96 h after a single intraperitoneal injection of Cd (5 mg kg-1) and of antioxidant substances (50 mg kg-1). Using
spectrophotometry, we determined the glutathione redox status, lipid peroxidation levels and the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione disulphide reductase (GR). Accumulation of Cd in the muscle was analysed using inductively coupled plasma - optical emission spectrometry (ICP-OES).
All substances lowered Cd levels in the following order of effi ciency; LA=NAC>TAU=CUR. Cadmium increased SOD activity, but CAT activity declined, regardless of antioxidant treatment. Treatment with
CUR induced GPx activity. Treatment with TAU lowered Cd due to higher total glutathione (tGSH). The most effective substances on lipid peroxidation were LA and NAC due to a greater Cd-lowering potential.
It seems that the protective role of TAU, LA, and NAC is not necessarily associated with antioxidant enzymes, but rather with their own activity.

Ključne riječi
accumulation; antioxidants; fish; muscle; oxidative stress

Hrčak ID: 65308

URI
https://hrcak.srce.hr/65308

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