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Kratko priopćenje
https://doi.org/10.2478/10004-1254-62-2011-2089
Long-Term Follow-Up Study of Genome Damage Elimination in Patients with Testicular Seminoma Exposed to Ionising Radiation during Radiotherapy
Marija Gamulin
; Clinical Hospital Centre Zagreb, Zagreb, Croatia
Jelena Katić
; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Mirta Milić
; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Mislav Grgić
; Clinical Hospital Centre Zagreb, Zagreb, Croatia
Alja Fučić
; Institute for Medical Research and Occupational Health, Zagreb, Croatia
| Puni tekst: engleski, pdf (151 KB) | str. 51-55 | citiraj | |
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APA 6th Edition Gamulin, M., Katić, J., Milić, M., Grgić, M. i Fučić, A. (2011). Long-Term Follow-Up Study of Genome Damage Elimination in Patients with Testicular Seminoma Exposed to Ionising Radiation during Radiotherapy. Arhiv za higijenu rada i toksikologiju, 62 (1), 51-55. https://doi.org/10.2478/10004-1254-62-2011-2089 MLA 8th Edition Gamulin, Marija, et al. "Long-Term Follow-Up Study of Genome Damage Elimination in Patients with Testicular Seminoma Exposed to Ionising Radiation during Radiotherapy." Arhiv za higijenu rada i toksikologiju, vol. 62, br. 1, 2011, str. 51-55. https://doi.org/10.2478/10004-1254-62-2011-2089. Citirano 22.10.2020. Chicago 17th Edition Gamulin, Marija, Jelena Katić, Mirta Milić, Mislav Grgić i Alja Fučić. "Long-Term Follow-Up Study of Genome Damage Elimination in Patients with Testicular Seminoma Exposed to Ionising Radiation during Radiotherapy." Arhiv za higijenu rada i toksikologiju 62, br. 1 (2011): 51-55. https://doi.org/10.2478/10004-1254-62-2011-2089 Harvard Gamulin, M., et al. (2011). 'Long-Term Follow-Up Study of Genome Damage Elimination in Patients with Testicular Seminoma Exposed to Ionising Radiation during Radiotherapy', Arhiv za higijenu rada i toksikologiju, 62(1), str. 51-55. https://doi.org/10.2478/10004-1254-62-2011-2089 Vancouver Gamulin M, Katić J, Milić M, Grgić M, Fučić A. Long-Term Follow-Up Study of Genome Damage Elimination in Patients with Testicular Seminoma Exposed to Ionising Radiation during Radiotherapy. Arh Hig Rada Toksikol. [Internet]. 2011 [pristupljeno 22.10.2020.];62(1):51-55. https://doi.org/10.2478/10004-1254-62-2011-2089 IEEE M. Gamulin, J. Katić, M. Milić, M. Grgić i A. Fučić, "Long-Term Follow-Up Study of Genome Damage Elimination in Patients with Testicular Seminoma Exposed to Ionising Radiation during Radiotherapy", Arhiv za higijenu rada i toksikologiju, vol.62, br. 1, str. 51-55, 2011. [Online]. https://doi.org/10.2478/10004-1254-62-2011-2089 |
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Sažetak
The rate of genome damage elimination after therapeutic exposure to ionising radiation was estimated in stage I testicular seminoma patients monitored over a seven-year follow-up. DNA damage elimination in peripheral lymphocytes of ten subjects was analysed by the chromosome aberration assay. Seven years after the end of radiotherapy, signifi cantly increased frequency of ring and dicentric chromosomes was still detected in comparison with baseline values. These results indicate the induction of genome instability.
Long-term follow-up studies of cancer patients after radiotherapy could give us valuable information on the rate of genome damage elimination after exposure to ionising radiation and about the duration and manifestation of genome instability. This may be used in health risk assessment related to the possible development of secondary neoplasia. Studies such as this could have a great value both for oncology and radiation protection management protocols, especially after accidental overexposures.
Ključne riječi
chromosome aberration assay; dicentric chromosome; follow-up; genome instability; ionising radiation; secondary cancer
Hrčak ID: 65314
URI
https://hrcak.srce.hr/65314
Moj profil
Srce