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Kratko priopćenje
https://doi.org/10.2478/10004-1254-62-2011-2089

Long-Term Follow-Up Study of Genome Damage Elimination in Patients with Testicular Seminoma Exposed to Ionising Radiation during Radiotherapy

Marija Gamulin ; Clinical Hospital Centre Zagreb, Zagreb, Croatia
Jelena Katić ; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Mirta Milić ; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Mislav Grgić ; Clinical Hospital Centre Zagreb, Zagreb, Croatia
Alja Fučić ; Institute for Medical Research and Occupational Health, Zagreb, Croatia

Puni tekst: engleski, pdf (151 KB) str. 51-55 preuzimanja: 381* citiraj
APA 6th Edition
Gamulin, M., Katić, J., Milić, M., Grgić, M. i Fučić, A. (2011). Long-Term Follow-Up Study of Genome Damage Elimination in Patients with Testicular Seminoma Exposed to Ionising Radiation during Radiotherapy. Arhiv za higijenu rada i toksikologiju, 62 (1), 51-55. https://doi.org/10.2478/10004-1254-62-2011-2089
MLA 8th Edition
Gamulin, Marija, et al. "Long-Term Follow-Up Study of Genome Damage Elimination in Patients with Testicular Seminoma Exposed to Ionising Radiation during Radiotherapy." Arhiv za higijenu rada i toksikologiju, vol. 62, br. 1, 2011, str. 51-55. https://doi.org/10.2478/10004-1254-62-2011-2089. Citirano 22.10.2020.
Chicago 17th Edition
Gamulin, Marija, Jelena Katić, Mirta Milić, Mislav Grgić i Alja Fučić. "Long-Term Follow-Up Study of Genome Damage Elimination in Patients with Testicular Seminoma Exposed to Ionising Radiation during Radiotherapy." Arhiv za higijenu rada i toksikologiju 62, br. 1 (2011): 51-55. https://doi.org/10.2478/10004-1254-62-2011-2089
Harvard
Gamulin, M., et al. (2011). 'Long-Term Follow-Up Study of Genome Damage Elimination in Patients with Testicular Seminoma Exposed to Ionising Radiation during Radiotherapy', Arhiv za higijenu rada i toksikologiju, 62(1), str. 51-55. https://doi.org/10.2478/10004-1254-62-2011-2089
Vancouver
Gamulin M, Katić J, Milić M, Grgić M, Fučić A. Long-Term Follow-Up Study of Genome Damage Elimination in Patients with Testicular Seminoma Exposed to Ionising Radiation during Radiotherapy. Arh Hig Rada Toksikol. [Internet]. 2011 [pristupljeno 22.10.2020.];62(1):51-55. https://doi.org/10.2478/10004-1254-62-2011-2089
IEEE
M. Gamulin, J. Katić, M. Milić, M. Grgić i A. Fučić, "Long-Term Follow-Up Study of Genome Damage Elimination in Patients with Testicular Seminoma Exposed to Ionising Radiation during Radiotherapy", Arhiv za higijenu rada i toksikologiju, vol.62, br. 1, str. 51-55, 2011. [Online]. https://doi.org/10.2478/10004-1254-62-2011-2089

Sažetak
The rate of genome damage elimination after therapeutic exposure to ionising radiation was estimated in stage I testicular seminoma patients monitored over a seven-year follow-up. DNA damage elimination in peripheral lymphocytes of ten subjects was analysed by the chromosome aberration assay. Seven years after the end of radiotherapy, signifi cantly increased frequency of ring and dicentric chromosomes was still detected in comparison with baseline values. These results indicate the induction of genome instability.
Long-term follow-up studies of cancer patients after radiotherapy could give us valuable information on the rate of genome damage elimination after exposure to ionising radiation and about the duration and manifestation of genome instability. This may be used in health risk assessment related to the possible development of secondary neoplasia. Studies such as this could have a great value both for oncology and radiation protection management protocols, especially after accidental overexposures.

Ključne riječi
chromosome aberration assay; dicentric chromosome; follow-up; genome instability; ionising radiation; secondary cancer

Hrčak ID: 65314

URI
https://hrcak.srce.hr/65314

[hrvatski]

Posjeta: 750 *