Medicina, Vol. 47 No. 1, 2011.
Kratko priopćenje
Genetic analysis of Y-chromosome microdeletions in men with a clinical diagnosis of schizophrenia
Tin Nadarević
; Zavod za biologiju i medicinsku genetiku, Medicinski fakultet Sveučilišta u Rijeci
Alena Buretić-Tomljanović
orcid.org/0000-0002-9840-1245
; Zavod za biologiju i medicinsku genetiku, Medicinski fakultet Sveučilišta u Rijeci
Sažetak
Aim: Fertility rate of patients with schizophrenia is lower than in the general population.
The contributing factors are sex, marital status, reproductive age, socioeconomic,
cultural, and genetic factors. In this work, we tested the possible genetic association between
schizophrenia and lower fertility rate of male patients. Patients and methods: DNA
samples taken from 105 male patients with clinical diagnosis of schizophrenia (according to
DSM-IV criteria) and 100 control men were analysed for the presence of chromosome Y
azoospermia factor (AZF) microdeletions. Six sequence tagged sites (STS) spanning AZFa-c
region were analysed using two multiplex polymerase chain reactions: sY84, sY127, sY254,
and sY86, sY134, sY255. STS-marker sY14 (Yp) and pseudoautosomal locus ZFX/ZFY were
used as control loci in both reactions. Results: No evidence of AZF-microdeletions were
found in both groups. Conclusion: Microdeletions of the chromosome Y AZF-region do not
contribute to the risk or reduced fertility rate in males with schizophrenia.
Ključne riječi
azoospermia factor; male fertility; schizophrenia
Hrčak ID:
66100
URI
Datum izdavanja:
7.3.2011.
Posjeta: 1.557 *