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https://doi.org/10.2478/v10007-011-0011-9

Development and characterization of mucoadhesive patches of salbutamol sulfate for unidirectional buccal drug delivery

AYRIVAN PURATCHIKODY ; Department of Pharmaceutical Technology, Anna University of Technology, Tiruchirapalli, Tiruchirapalli-620 024, India
VISWANADHAN VASANTHA PRASANTH ; Department of Pharmaceutics, Gautham College of Pharmacy, Sultanpalya, Bangalore-560 032, India
SAM THOMAS MATHEW ; Document Operations in Clinical, Novartis Health Care Pvt Ltd, Hyderabad-500 072, India
BALARAMAN ASHOK KUMAR ; Department of Pharmaceutical Chemistry, Jadavpur University, Kolkata-700 032, India

Puni tekst: engleski, pdf (209 KB) str. 157-170 preuzimanja: 694* citiraj
APA 6th Edition
PURATCHIKODY, A., PRASANTH, V.V., MATHEW, S.T. i KUMAR, B.A. (2011). Development and characterization of mucoadhesive patches of salbutamol sulfate for unidirectional buccal drug delivery. Acta Pharmaceutica, 61 (2), 157-170. https://doi.org/10.2478/v10007-011-0011-9
MLA 8th Edition
PURATCHIKODY, AYRIVAN, et al. "Development and characterization of mucoadhesive patches of salbutamol sulfate for unidirectional buccal drug delivery." Acta Pharmaceutica, vol. 61, br. 2, 2011, str. 157-170. https://doi.org/10.2478/v10007-011-0011-9. Citirano 18.06.2019.
Chicago 17th Edition
PURATCHIKODY, AYRIVAN, VISWANADHAN VASANTHA PRASANTH, SAM THOMAS MATHEW i BALARAMAN ASHOK KUMAR. "Development and characterization of mucoadhesive patches of salbutamol sulfate for unidirectional buccal drug delivery." Acta Pharmaceutica 61, br. 2 (2011): 157-170. https://doi.org/10.2478/v10007-011-0011-9
Harvard
PURATCHIKODY, A., et al. (2011). 'Development and characterization of mucoadhesive patches of salbutamol sulfate for unidirectional buccal drug delivery', Acta Pharmaceutica, 61(2), str. 157-170. doi: https://doi.org/10.2478/v10007-011-0011-9
Vancouver
PURATCHIKODY A, PRASANTH VV, MATHEW ST, KUMAR BA. Development and characterization of mucoadhesive patches of salbutamol sulfate for unidirectional buccal drug delivery. Acta Pharm. [Internet]. 2011 [pristupljeno 18.06.2019.];61(2):157-170. doi: https://doi.org/10.2478/v10007-011-0011-9
IEEE
A. PURATCHIKODY, V.V. PRASANTH, S.T. MATHEW i B.A. KUMAR, "Development and characterization of mucoadhesive patches of salbutamol sulfate for unidirectional buccal drug delivery", Acta Pharmaceutica, vol.61, br. 2, str. 157-170, 2011. [Online]. doi: https://doi.org/10.2478/v10007-011-0011-9

Sažetak
Buccal patches of salbutamol sulfate were prepared using five different water soluble polymers in various proportions and combinations using PEG-400/PG as plasticizers. A 32 full factorial design was used to design the experiments for each polymer combination. Patches were laminated on one side with a water impermeable backing layer for unidirectional drug release. The thickness of medicated patches ranged between 0.2 and 0.4 mm and showed an increase in mass whenever PEG-400 was used as plasticizer. The surface pH of all patches approached neutral. Eight formulations which had shown high folding endurance (> 300) were selected for evaluation. Patches prepared with PEG-400 showed a high swelling index. The residence time of the tested patches ranged between 105 and 130 min. Formulations A10, A32, B10 and B32 fitted the Higuchi model best, whereas formulations A19 and B19 showed super case II transport drug release. Stability studies indicated that there was no change in the chemical and physical characteristics during the test period of 6 months.

Ključne riječi
salbutamol sulfate; mucoadhesive patches; buccal drug delivery; 32 full factorial design

Hrčak ID: 66182

URI
https://hrcak.srce.hr/66182

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Posjeta: 891 *