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Kratko priopćenje
https://doi.org/10.2478/v10007-011-0014-6

Synthesis, antispasmodic and antidiarrheal activities of some 1-substituted imidazole derivatives

BASKAR LAKSHMANAN ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand-835215, India
PAPIYA MITRA MAZUMDER ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand-835215, India
DINAKAR SASMAL ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand-835215, India
SWASTIKA GANGULY ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand-835215, India

Puni tekst: engleski, pdf (130 KB) str. 227-236 preuzimanja: 931* citiraj
APA 6th Edition
LAKSHMANAN, B., MAZUMDER, P.M., SASMAL, D. i GANGULY, S. (2011). Synthesis, antispasmodic and antidiarrheal activities of some 1-substituted imidazole derivatives. Acta Pharmaceutica, 61 (2), 227-236. https://doi.org/10.2478/v10007-011-0014-6
MLA 8th Edition
LAKSHMANAN, BASKAR, et al. "Synthesis, antispasmodic and antidiarrheal activities of some 1-substituted imidazole derivatives." Acta Pharmaceutica, vol. 61, br. 2, 2011, str. 227-236. https://doi.org/10.2478/v10007-011-0014-6. Citirano 21.10.2019.
Chicago 17th Edition
LAKSHMANAN, BASKAR, PAPIYA MITRA MAZUMDER, DINAKAR SASMAL i SWASTIKA GANGULY. "Synthesis, antispasmodic and antidiarrheal activities of some 1-substituted imidazole derivatives." Acta Pharmaceutica 61, br. 2 (2011): 227-236. https://doi.org/10.2478/v10007-011-0014-6
Harvard
LAKSHMANAN, B., et al. (2011). 'Synthesis, antispasmodic and antidiarrheal activities of some 1-substituted imidazole derivatives', Acta Pharmaceutica, 61(2), str. 227-236. https://doi.org/10.2478/v10007-011-0014-6
Vancouver
LAKSHMANAN B, MAZUMDER PM, SASMAL D, GANGULY S. Synthesis, antispasmodic and antidiarrheal activities of some 1-substituted imidazole derivatives. Acta Pharm. [Internet]. 2011 [pristupljeno 21.10.2019.];61(2):227-236. https://doi.org/10.2478/v10007-011-0014-6
IEEE
B. LAKSHMANAN, P.M. MAZUMDER, D. SASMAL i S. GANGULY, "Synthesis, antispasmodic and antidiarrheal activities of some 1-substituted imidazole derivatives", Acta Pharmaceutica, vol.61, br. 2, str. 227-236, 2011. [Online]. https://doi.org/10.2478/v10007-011-0014-6

Sažetak
A series of 1-substituted imidazoles 1a-d and 2a-d were synthesized and screened for antispasmodic and antidiarrheal activities. Antispasmodic activity was tested at various concentrations on isolated tissue preparations; concentration-response curves were plotted and compared with atropine. All compounds were found to inhibit contraction of the guinea pig ileum. Castor oil-induced diarrhea model in rats was used for evaluation of antidiarrheal activity. Parameters such as intestinal transit and volume of intestinal fluid were measured for antidiarrheal activity at 40 mg kg-1 dose and compared with the standard drug loperamide at a 6 mg kg1 dose. Defecation frequency in the test group was found to be significantly lower (p < 0.01) compared to the control group and comparable with that of the standard. The present study reveals that the compounds exert antidiarrheal activity through possible inhibition of intestinal movement and reduction of capillary permeability in the abdominal cavity.

Ključne riječi
1-substituted imidazoles; antispasmodic; antidiarrheal; gastro-intestinal transit

Hrčak ID: 66185

URI
https://hrcak.srce.hr/66185

[hrvatski]

Posjeta: 1.161 *