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Acta Pharmaceutica, Vol. 61 No. 2, 2011.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-011-0017-3

Formulation and evaluation of mucoadhesive glipizide films

GANESH RAJPUT ; Nootan Pharmacy College, S. P. Vidyadham, Visnagar-384315, India
FALGUNI MAJMUDAR ; N.H.L Municipal Medical College, Ahmedabad, India
JAYVADAN PATEL ; Nootan Pharmacy College, S. P. Vidyadham, Visnagar-384315, India

Puni tekst: engleski, pdf (121 KB) str. 203-216 preuzimanja: 726* citiraj
APA 6th Edition
RAJPUT, G., MAJMUDAR, F. i PATEL, J. (2011). Formulation and evaluation of mucoadhesive glipizide films. Acta Pharmaceutica, 61 (2), 203-216. https://doi.org/10.2478/v10007-011-0017-3
MLA 8th Edition
RAJPUT, GANESH, et al. "Formulation and evaluation of mucoadhesive glipizide films." Acta Pharmaceutica, vol. 61, br. 2, 2011, str. 203-216. https://doi.org/10.2478/v10007-011-0017-3. Citirano 15.02.2019.
Chicago 17th Edition
RAJPUT, GANESH, FALGUNI MAJMUDAR i JAYVADAN PATEL. "Formulation and evaluation of mucoadhesive glipizide films." Acta Pharmaceutica 61, br. 2 (2011): 203-216. https://doi.org/10.2478/v10007-011-0017-3
Harvard
RAJPUT, G., MAJMUDAR, F., i PATEL, J. (2011). 'Formulation and evaluation of mucoadhesive glipizide films', Acta Pharmaceutica, 61(2), str. 203-216. doi: https://doi.org/10.2478/v10007-011-0017-3
Vancouver
RAJPUT G, MAJMUDAR F, PATEL J. Formulation and evaluation of mucoadhesive glipizide films. Acta Pharm. [Internet]. 2011 [pristupljeno 15.02.2019.];61(2):203-216. doi: https://doi.org/10.2478/v10007-011-0017-3
IEEE
G. RAJPUT, F. MAJMUDAR i J. PATEL, "Formulation and evaluation of mucoadhesive glipizide films", Acta Pharmaceutica, vol.61, br. 2, str. 203-216, 2011. [Online]. doi: https://doi.org/10.2478/v10007-011-0017-3

Sažetak
Glipizide is mainly absorbed in the proximal areas of the gastrointestinal tract. The purpose of this study was formulation and evaluation of mucoadhesive films to prolong the stay of drug in its absorption area. Glipizide was formulated in a mucoadhesive film that could be retained in the stomach for prolonged time intervals. Polymeric films were designed with various compositions of hydroxypropyl cellulose and polyethylene glycol 400 (PEG 400). Properties of the mucoadhesive film such as tensile strength, percentage elongation, swelling index, moisture content, pH and viscosity of polymeric dispersion, film thickness, drug concentration, uniformity and mucoadhesion in a simulated gastric environment were evaluated. In addition, percentage drug retained in stomach mucosa was estimated using a simulated dynamic stomach system as a function of time. Increase in hydroxypropyl cellulose concentration resulted in a higher tensile strength and elongation at break, while increase in concentration of PEG 400 was reflected in a decrease of tensile strength and increase of elongation at break. Glipizide/hydroxypropyl cellulose/PEG 400 (2.5:1:0.5) (GF5) was found to be the optimal composition for a novel mucoadhesive stomach formulation that showed good peelability, relatively high swelling index, moderate tensile strength, and stayed on rat stomach mucosa up to 8 h. In vivo testing of the mucoadhesive films with glipizide demonstrated a potential hypoglycemic effect.

Ključne riječi
glipizide; mucoadhesive film; factorial design; desirability function; hypoglycemic effect

Hrčak ID: 66188

URI
https://hrcak.srce.hr/66188

[hrvatski]

Posjeta: 981 *