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Acta Pharmaceutica, Vol. 61 No. 2, 2011.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-011-0019-1

Sinteza i antimikrobno vrednovanje nekoliko 6-aril-5-cijano-2-tiouracil derivata

MOSAAD SAYED MOHAMED ; Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt
SAMIR MOHAMED AWAD ; Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt
NAGLAA MOHAMED Ahmed ; Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt

Puni tekst: engleski, pdf (108 KB) str. 171-185 preuzimanja: 931* citiraj
APA 6th Edition
MOHAMED, M.S., AWAD, S.M. i Ahmed, N.M. (2011). Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivatives. Acta Pharmaceutica, 61 (2), 171-185. https://doi.org/10.2478/v10007-011-0019-1
MLA 8th Edition
MOHAMED, MOSAAD SAYED, et al. "Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivatives." Acta Pharmaceutica, vol. 61, br. 2, 2011, str. 171-185. https://doi.org/10.2478/v10007-011-0019-1. Citirano 24.02.2019.
Chicago 17th Edition
MOHAMED, MOSAAD SAYED, SAMIR MOHAMED AWAD i NAGLAA MOHAMED Ahmed. "Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivatives." Acta Pharmaceutica 61, br. 2 (2011): 171-185. https://doi.org/10.2478/v10007-011-0019-1
Harvard
MOHAMED, M.S., AWAD, S.M., i Ahmed, N.M. (2011). 'Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivatives', Acta Pharmaceutica, 61(2), str. 171-185. doi: https://doi.org/10.2478/v10007-011-0019-1
Vancouver
MOHAMED MS, AWAD SM, Ahmed NM. Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivatives. Acta Pharm. [Internet]. 2011 [pristupljeno 24.02.2019.];61(2):171-185. doi: https://doi.org/10.2478/v10007-011-0019-1
IEEE
M.S. MOHAMED, S.M. AWAD i N.M. Ahmed, "Synthesis and antimicrobial evaluation of some 6-aryl-5-cyano-2-thiouracil derivatives", Acta Pharmaceutica, vol.61, br. 2, str. 171-185, 2011. [Online]. doi: https://doi.org/10.2478/v10007-011-0019-1

Sažetak
Polazeći iz etil-cijanoacetata, tiouree i odgovarajućeg aldehida sintetizirana je serija (6-aril-5-cijano)-2-tiouracil derivata (1a-d), koji su potom upotrijebljeni za dobivanje tiouracil derivata (2a-d do 10a-d). Svim spojevima ispitano je antibakterijsko i antimikotsko djelovanje. Neki od sintetiziranih spojeva, 6-(4-fluorofenil)-4-okso-2-tiokso-1,2,3,4-tetrahidropirimidin-5-karboksamid (2a), 4-okso-2-tiokso-6-(3,4,5-trimetoksifenil)-1,2,3,4-tetrahidropirimidin-5-karboksamid (2d), 6-(4-fluorofenil)-4-hidrazino-2-tiokso-1,2-dihidropirimidin-5-kabonitril (7a) i 4-hidrazino-2-tiokso-6-(3,4,5-trimetoksifenil)-1,2-dihidropirimidin-5-karbonitril (7d) imaju značajno antimikrobno djelovanje.

Ključne riječi
6-aril-5-cijano-2-tiouracil; antibakterijsko djelovanje; antimikotsko djelovanje

Hrčak ID: 66190

URI
https://hrcak.srce.hr/66190

[engleski]

Posjeta: 1.187 *